Assessment of iris surface features and their relationship with iris thickness in Asian eyes.
Ophthalmology
; 121(5): 1007-12, 2014 May.
Article
em En
| MEDLINE
| ID: mdl-24405741
ABSTRACT
PURPOSE:
To assess iris surface features in Asian eyes and examine their associations with iris thickness measured by anterior segment optical coherence tomography (AS OCT).DESIGN:
Cross-sectional study.PARTICIPANTS:
We recruited 250 subjects from the Singapore Malay Eye Study.METHODS:
We obtained standardized slit-lamp photographs and developed a grading system assessing iris crypts (by number and size), furrows (by number and circumferential extent), and color (higher grade denoting darker iris). Vertical and horizontal cross-sections of the anterior chamber were imaged using AS OCT. Intragrader and intergrader agreements in the grading of iris surface were assessed by weighted κ (κ(w)) statistic. Associations of the average iris thickness with the grade of iris features were assessed using linear regression analysis. MAIN OUTCOMEMEASURES:
Frequency and size of iris crypts, furrows, and color; iris thickness at 750 µm (IT750) and 2000 µm (IT2000) from the scleral spur; and maximum iris thickness (ITM) averaged from the 4 quarters.RESULTS:
Three hundred sixty-four eyes had complete and gradable data for crypts and color; 330 eyes were graded for furrows. The grading scheme showed good intragrader (crypt κ(w) = 0.919, furrow κ(w) =0.901, color κ(w) = 0.925) and intergrader (crypt κ(w) = 0.775, furrow κ(w) = 0.836, color κ(w) = 0.718) agreements. Higher crypt grade was associated independently with thinner IT750 (ß [change in iris thickness per grade higher] = -0.007; P = 0.029), IT2000 (ß = -0.018; P < 0.001), and ITM (ß = -0.012; P < 0.001). More extensive furrows were associated with thicker IT750 (ß = 0.022; P < 0.001). Darker iris was also associated with thicker IT750 (ß = 0.014; P = 0.001).CONCLUSIONS:
Iris surface features, assessed and measured from slit-lamp photographs, correlate well with iris thickness. Irises with more crypts are thinner; irises with more extensive furrows and darker color are thicker peripherally. These findings may provide another means to assess angle closure risk based on iris features.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Iris
/
Povo Asiático
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Ophthalmology
Ano de publicação:
2014
Tipo de documento:
Article