A point-based tool to predict conversion from mild cognitive impairment to probable Alzheimer's disease.
Alzheimers Dement
; 10(6): 646-55, 2014 Nov.
Article
em En
| MEDLINE
| ID: mdl-24495339
BACKGROUND: Our objective in this study was to develop a point-based tool to predict conversion from amnestic mild cognitive impairment (MCI) to probable Alzheimer's disease (AD). METHODS: Subjects were participants in the first part of the Alzheimer's Disease Neuroimaging Initiative. Cox proportional hazards models were used to identify factors associated with development of AD, and a point score was created from predictors in the final model. RESULTS: The final point score could range from 0 to 9 (mean 4.8) and included: the Functional Assessment Questionnaire (2â3 points); magnetic resonance imaging (MRI) middle temporal cortical thinning (1 point); MRI hippocampal subcortical volume (1 point); Alzheimer's Disease Cognitive Scale-cognitive subscale (2â3 points); and the Clock Test (1 point). Prognostic accuracy was good (Harrell's c = 0.78; 95% CI 0.75, 0.81); 3-year conversion rates were 6% (0â3 points), 53% (4â6 points), and 91% (7â9 points). CONCLUSIONS: A point-based risk score combining functional dependence, cerebral MRI measures, and neuropsychological test scores provided good accuracy for prediction of conversion from amnestic MCI to AD.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Alzheimer
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Disfunção Cognitiva
Tipo de estudo:
Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Aged80
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Female
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Humans
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Male
Idioma:
En
Revista:
Alzheimers Dement
Ano de publicação:
2014
Tipo de documento:
Article