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Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome.
Menon, Suchithra; Dibble, Christian C; Talbott, George; Hoxhaj, Gerta; Valvezan, Alexander J; Takahashi, Hidenori; Cantley, Lewis C; Manning, Brendan D.
Afiliação
  • Menon S; Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
  • Dibble CC; Department of Systems Biology, Harvard Medical School and Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. Electronic address: ccdibble@bidmc.harvard.edu.
  • Talbott G; Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
  • Hoxhaj G; Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
  • Valvezan AJ; Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
  • Takahashi H; Department of Systems Biology, Harvard Medical School and Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
  • Cantley LC; Department of Systems Biology, Harvard Medical School and Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA; Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
  • Manning BD; Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA. Electronic address: bmanning@hsph.harvard.edu.
Cell ; 156(4): 771-85, 2014 Feb 13.
Article em En | MEDLINE | ID: mdl-24529379
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complexos Multiproteicos / Serina-Treonina Quinases TOR / Insulina / Lisossomos Limite: Animals / Humans Idioma: En Revista: Cell Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complexos Multiproteicos / Serina-Treonina Quinases TOR / Insulina / Lisossomos Limite: Animals / Humans Idioma: En Revista: Cell Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos