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Molecular responses to hypoxia-inducible factor 1α and beyond.
Brocato, Jason; Chervona, Yana; Costa, Max.
Afiliação
  • Brocato J; Department of Environmental Medicine, New York University Langone Medical Center, Tuxedo, New York.
Mol Pharmacol ; 85(5): 651-7, 2014 May.
Article em En | MEDLINE | ID: mdl-24569087
Cellular response to changes in oxygen tension during normal development or pathologic processes is, in part, regulated by hypoxia-inducible factor (HIF), an oxygen-sensitive transcription factor. HIF activity is primarily controlled through post-translational modifications and stabilization of HIF-1α and HIF-2α proteins and is regulated by a number of cellular pathways involving both oxygen-dependent and -independent mechanisms. Stabilization of HIF-1α activates transcription of genes that participate in key pathways in carcinogenesis, such as angiogenesis, dedifferentiation, and invasion. Since its discovery more than two decades ago, HIF-1α has become a hot topic in molecular research and has been implicated not only in disease pathology but also in prognosis. In this review, we will focus on recent insights into HIF-1α regulation, function, and gene expression. We will also discuss emerging data on the involvement of HIF in cancer prognosis and therapeutic interventions.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Subunidade alfa do Fator 1 Induzível por Hipóxia Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Mol Pharmacol Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Subunidade alfa do Fator 1 Induzível por Hipóxia Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Mol Pharmacol Ano de publicação: 2014 Tipo de documento: Article