Estrogen receptor mutations in breast cancer--new focus on an old target.
Clin Cancer Res
; 20(7): 1724-6, 2014 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-24583794
ABSTRACT
Recent studies have provided strong evidence for the emergence of substantial numbers of constitutively active ESR1 mutations in estrogen receptor-positive metastatic breast cancer that are undetected in primary disease. Some of these mutants remain partially sensitive to current anti-estrogen therapies but effective therapeutics targeted at them may require new approaches.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Receptor alfa de Estrogênio
/
Mutação
/
Neoplasias Hormônio-Dependentes
Limite:
Female
/
Humans
Idioma:
En
Revista:
Clin Cancer Res
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Reino Unido