Novel S-adenosyl-L-methionine decarboxylase inhibitors as potent antiproliferative agents against intraerythrocytic Plasmodium falciparum parasites.

le Roux, Dina; Burger, Pieter B; Niemand, Jandeli; Grobler, Anne; Urbán, Patricia; Fernàndez-Busquets, Xavier; Barker, Robert H; Serrano, Adelfa E; I Louw, Abraham; Birkholtz, Lyn-Marie

le Roux, Dina; Burger, Pieter B; Niemand, Jandeli; Grobler, Anne; Urbán, Patricia; Fernàndez-Busquets, Xavier; Barker, Robert H; Serrano, Adelfa E; I Louw, Abraham; Birkholtz, Lyn-Marie.

Afiliação

le Roux D; Department of Biochemistry, Centre for Sustainable Malaria Control, University of Pretoria, Private Bag X20, Hatfield 0028, South Africa.
Burger PB; Department of Biochemistry, Centre for Sustainable Malaria Control, University of Pretoria, Private Bag X20, Hatfield 0028, South Africa.
Niemand J; Department of Biochemistry, Centre for Sustainable Malaria Control, University of Pretoria, Private Bag X20, Hatfield 0028, South Africa.
Grobler A; DST/NWU Preclinical Drug Development Platform, North-West University, Potchefstroom 2531, South Africa.
Urbán P; Nanobioengineering Group, Institute for Bioengineering of Catalonia, Baldiri Reixac 10-12, Barcelona E08028, Spain ; Barcelona Centre for International Health Research (CRESIB), Hospital Clínic-Universitat de Barcelona, Rosselló 149-153, Barcelona E08036, Spain ; Biomolecular Interactions Team, Nano
Fernàndez-Busquets X; Nanobioengineering Group, Institute for Bioengineering of Catalonia, Baldiri Reixac 10-12, Barcelona E08028, Spain ; Barcelona Centre for International Health Research (CRESIB), Hospital Clínic-Universitat de Barcelona, Rosselló 149-153, Barcelona E08036, Spain ; Biomolecular Interactions Team, Nano
Barker RH; Genzyme Corporation, 153 Second Avenue, Waltham, MA 02451, USA.
Serrano AE; University of Puerto Rico-School of Medicine, Department of Microbiology and Medical Zoology, P.O. Box 365067, San Juan PR 00936-5067, Puerto Rico.
I Louw A; Department of Biochemistry, Centre for Sustainable Malaria Control, University of Pretoria, Private Bag X20, Hatfield 0028, South Africa.
Birkholtz LM; Department of Biochemistry, Centre for Sustainable Malaria Control, University of Pretoria, Private Bag X20, Hatfield 0028, South Africa.

Int J Parasitol Drugs Drug Resist ; 4(1): 28-36, 2014 Apr.

Article em En | MEDLINE | ID: mdl-24596666

Palavras-chave

AdoMet, S-adenosyl-l-methionine; AdoMetDC, S-adenosyl-l-methionine decarboxylase; DFMO, dl-α-difluoromethylornithine; Genz-644043, 2'-fluoro-5'-{[(Z)-4-amino-2-butenyl]methylamino}-5'-deoxyadenosine; Genz-644053, 2-chloro-5'-{[(Z)-4-amino-2-butenyl]methylamino}-5'-deoxyadenosine; Genz-644131, 8-methyl-5'-{[(Z)-4-aminobut-2-enyl]methylamino}-5'-deoxyadenosine; Immunoliposomes; MDL73811, 5'-{[(Z)-4-amino-2-butenyl]methylamino}-5'-deoxyadenosine; ODC, ornithine decarboxylase; Plasmodium; Polyamines; S-adenosyl-l-methionine decarboxylase; dcAdoMet, decarboxylated S-adenosyl-l-methionine

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Int J Parasitol Drugs Drug Resist Ano de publicação: 2014 Tipo de documento: Article País de afiliação: África do Sul

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