A human short open reading frame (sORF)-encoded polypeptide that stimulates DNA end joining.
J Biol Chem
; 289(16): 10950-10957, 2014 Apr 18.
Article
em En
| MEDLINE
| ID: mdl-24610814
ABSTRACT
The recent discovery of numerous human short open reading frame (sORF)-encoded polypeptides (SEPs) has raised important questions about the functional roles of these molecules in cells. Here, we show that a 69-amino acid SEP, MRI-2, physically interacts with the Ku heterodimer to stimulate DNA double-strand break ligation via nonhomologous end joining. The characterization of MRI-2 suggests that this SEP may participate in DNA repair and underscores the potential of SEPs to serve important biological functions in mammalian cells.
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Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fases de Leitura Aberta
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DNA Helicases
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Quebras de DNA de Cadeia Dupla
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Reparo do DNA por Junção de Extremidades
Limite:
Humans
Idioma:
En
Revista:
J Biol Chem
Ano de publicação:
2014
Tipo de documento:
Article