Robust rat pulmonary radioprotection by a lipophilic Mn N-alkylpyridylporphyrin, MnTnHex-2-PyP(5+).
Redox Biol
; 2: 400-10, 2014.
Article
em En
| MEDLINE
| ID: mdl-24624330
Palavras-chave
8-OHdG, 8-hydroxy-2'-deoxyguanosine; AKT, protein kinase B (PKB), a serine/threonine-specific protein kinase; ALS, amyotrophic laterial sclerosis; AP-1, activator protein-1; AT, ataxia telangiectasia; BBB, blood brain barrier; Breathing frequencies; CNS, central nervous system; CO3−, carbonate radical; ClO−, hypochlorite; ETC, mitochondrial electron transport chain; Fischer rats; GMP, good manufacturing practice; GS−, monodeprotonated glutathione; HIF-1α, hypoxia inducible factor-1; HO2−, monodeprotonated hydrogen peroxide; Histopathology; I/R, ischemia reperfusion; Immunohistochemistry; Lung injury; MCAO, middle cerebral artery occlusion; Manganese porphyrins; MnP, Mn porphyrin; MnTDE-2-ImP5+, Mn(III) tetrakis[N,N'-diethylimidazolium-2-yl)porphyrin, AEOL10150; MnTE-2-PyP5+; MnTE-2-PyP5+, Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin (AEOL10113); MnTnBuOE-2-PyP5+, Mn(III) meso-tetrakis(N-(n-butoxyethyl)pyridinium-2-yl)porphyrin; MnTnHex-2-PyP5+; MnTnHex-2-PyP5+, Mn(III) meso-tetrakis(N-(n-hexyl)pyridinium-2-yl)porphyrin (AEOL10113); NF-κB, nuclear factor κB; NHE, normal hydrogen electrode; NO, nitric oxide; NOX4, NADPH oxidase, isoform 4 E1/2, Half-wave metal-centered reduction potential; Nrf-2, nuclear factor-erythroid-derived 2-like 2; O2−, superoxide; ONOO−, peroxynitrite; PI3K, phosphatidylinositide 3-kinase; PTEN, phosphoinositide 3-phosphatase; Radioprotection; Redox-modulators; SAH, subarachnoid hemorrhage; SOD, superoxide dismutase; SP-1, specificity protein-1; TF, transcription factor; TGF-ß1, one of the 3 members of the TGF-ß transforming growth factor-ß family; VEGF, vascular endothelial growth factor; mTOR, mammalian target of rapamycin (mTOR), a serine/threonine protein kinase
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Protetores contra Radiação
/
Pulmão
/
Metaloporfirinas
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Redox Biol
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Alemanha