Aspartame and the rat brain monoaminergic system.
Toxicol Lett
; 44(3): 331-9, 1988 Dec.
Article
em En
| MEDLINE
| ID: mdl-2464204
ABSTRACT
A high dose of aspartame (APM) was administered to rats to study possible effects on brain monoaminergic systems. APM and its metabolite phenylalanine (Phe) were given orally at doses of 1000 and 500 mg/kg, respectively. Significant increases were seen in brain Phe and tyrosine (Tyr) levels. Two different approaches were used to study monoaminergic systems whole tissue measurements by HPLC-ED and in vivo voltammetry in freely moving rats. Dopamine, serotonin and their metabolites were taken as indexes of neuronal activity. In spite of the high dose used, no modification was found in monoamines or their metabolites in striatum, hippocampus and nucleus accumbens.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aspartame
/
Encéfalo
/
Monoaminas Biogênicas
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Dipeptídeos
Limite:
Animals
Idioma:
En
Revista:
Toxicol Lett
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
Itália