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The validity of circulating microRNAs in oncology: five years of challenges and contradictions.
Jarry, J; Schadendorf, D; Greenwood, C; Spatz, A; van Kempen, L C.
Afiliação
  • Jarry J; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.
  • Schadendorf D; Department of Dermatology, University Hospital Essen, Germany.
  • Greenwood C; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada; Department of Human Genetics, McGill University, Montreal, QC, Canada; Department of Oncology, McGill
  • Spatz A; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada; Department of Pathology, Jewish General Hospital, Montreal, QC, Canada; Department of Oncology, McGill University, Montreal, QC, Canada; Department of Pathology, McGill University, Montreal, QC, Canada.
  • van Kempen LC; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada; Department of Pathology, Jewish General Hospital, Montreal, QC, Canada; Department of Pathology, McGill University, Montreal, QC, Canada. Electronic address: Leon.vankempen@mcgill.ca.
Mol Oncol ; 8(4): 819-29, 2014 Jun.
Article em En | MEDLINE | ID: mdl-24656978
ABSTRACT
MicroRNAs (miRNAs) in circulation have received an increasing amount of interest as potential minimal invasive diagnostic tools in oncology. Several diagnostic, prognostic and predictive signatures have been proposed for a variety of cancers at different stages of disease, but these have not been subjected to a critical review regarding their validity reproducible identification in comparable studies and/or with different platforms of miRNA detection. In this review, we will critically address the results of circulating miRNA research in oncology that have been published between January 2008 and June 2013 (5.5 years), and discuss pre-analytical challenges, technological pitfalls and limitations that may contribute to the non-reproducibility of circulating miRNA research.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Análise Química do Sangue / MicroRNAs / Neoplasias Tipo de estudo: Evaluation_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Mol Oncol Assunto da revista: BIOLOGIA MOLECULAR / NEOPLASIAS Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Canadá
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Análise Química do Sangue / MicroRNAs / Neoplasias Tipo de estudo: Evaluation_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Mol Oncol Assunto da revista: BIOLOGIA MOLECULAR / NEOPLASIAS Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Canadá