Inhibition of murine fibrocyte differentiation by cross-linked IgG is dependent on FcγRI.
J Leukoc Biol
; 96(2): 275-82, 2014 Aug.
Article
em En
| MEDLINE
| ID: mdl-24752483
ABSTRACT
Monocyte-derived, fibroblast-like cells, called fibrocytes, participate in wound-healing and the formation of fibrotic lesions. Aggregated or cross-linked IgG are key effectors in infections, autoimmune diseases, anaphylaxis, and immunotherapy. Cells, including monocytes and fibrocytes, bind IgG using FcγRs, and aggregated or cross-linked IgG inhibits fibrocyte differentiation. Mice have four different FcγRs, and which of these, if any, mediate the cross-linked IgG effect on fibrocyte differentiation is unknown. We find that in mice, deletion of FcγRI or the common signaling protein FcRγ significantly reduces the ability of cross-linked IgG or IgG2a to inhibit fibrocyte differentiation. Cells from FcγRIIb/III/IV KO mice are still sensitive to cross-linked IgG, whereas cells from FcγRI/IIb/III/IV KO mice are insensitive to cross-linked IgG. These observations suggest that IgG-mediated inhibition of fibrocyte differentiation is mediated by FcγRs, with FcγRI mediating most of the signaling.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina G
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Transdução de Sinais
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Diferenciação Celular
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Receptores de IgG
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Fibroblastos
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Capeamento Imunológico
Limite:
Animals
Idioma:
En
Revista:
J Leukoc Biol
Ano de publicação:
2014
Tipo de documento:
Article