Interactions of interferons in the induction of histocompatibility antigens in mouse fibroblasts and glial cells.
Immunology
; 67(4): 537-9, 1989 Aug.
Article
em En
| MEDLINE
| ID: mdl-2475435
ABSTRACT
The interactive effects of interferons (IFN) in the induction of class II major histocompatibility complex (MHC) antigens in a murine fibroblast line and murine glial cells (primary astrocytes and an oligodendroglioma line) were examined. It was found that IFN-alpha and -beta were additive with IFN-gamma in the induction of class I antigens but that both IFN-alpha and -beta down-regulated the induction of class II antigens by IFN-gamma. This was most clear cut when the IFN-alpha or -beta was present in large excess in terms of anti-viral activity. Recombinant IFN-alpha 2 was found weakly to induce class II antigens, unlike natural IFN-alpha. The results imply that IFN-alpha and -beta may be important in the control of class II antigen expression in vivo although not by themselves inducing class II antigens.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antígenos de Histocompatibilidade Classe II
/
Interferons
Limite:
Animals
Idioma:
En
Revista:
Immunology
Ano de publicação:
1989
Tipo de documento:
Article
País de afiliação:
Reino Unido