The prognostic role of circulating tumor cells in heavily pretreated individuals with a low life expectancy.
Future Oncol
; 10(16): 2555-60, 2014 Dec.
Article
em En
| MEDLINE
| ID: mdl-24877667
ABSTRACT
AIMS:
Studies of circulating tumor cells (CTCs) have generally recruited individuals with newly diagnosed metastatic cancer, with recent data also indicating their prognostic value in the adjuvant setting. Their role in dying patients has not been established. EXPERIMENTAL CTCs were measured in 43 individuals with metastatic breast cancer estimated to have less than 6 months to live who had exhausted standard therapeutic options.RESULTS:
Those with a CTC count of ≤ 100 had a median of 182 days to live, compared with those with a CTC count of >100 who had a median of 17 days until death (p = 0.009, log rank, HR 3.1, 95% CI 1.4-7.3).CONCLUSION:
A CTC count of >100 is associated with imminent death. Provided external validity is demonstrated, such information would be useful for patients and their families who often request specific prognostic clarity and could improve the quality of end-of-life care.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Prognóstico
/
Neoplasias da Mama
/
Biomarcadores Tumorais
/
Células Neoplásicas Circulantes
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Aged
/
Aged80
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
Future Oncol
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Reino Unido