Dermal administration of manganese porphyrin by iontophoresis.
Mater Sci Eng C Mater Biol Appl
; 41: 349-53, 2014 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-24907770
ABSTRACT
The present study describes a technique for dermal administration of cationic manganese porphyrin (Mn-porphyrin), an antioxidant with superoxide dismutase (SOD) activity, in hairless mouse. In general, the stratum corneum on the surface of the skin represents a barrier to passive diffusion of therapeutic agents by standard dermal administration. The present study investigated whether, dermal administration of Mn-porphyrin solution using iontophoresis, the electrical dermal administration technique, could overcome this barrier. We visually confirmed that Mn-porphyrin had penetrated to the reverse side of the hairless mouse skin after iontophoresis for a short period. With prolonged iontophoresis, the ratio of detectable Mn-porphyrin solution on the reverse side of the hairless mouse skin increased. In the future, this technique could provide an innovative approach for delivery of this antioxidant in intractable disease.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Porfirinas
/
Iontoforese
/
Manganês
/
Antioxidantes
Limite:
Animals
Idioma:
En
Revista:
Mater Sci Eng C Mater Biol Appl
Ano de publicação:
2014
Tipo de documento:
Article