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The clinical pharmacogenetics implementation consortium guideline for SLCO1B1 and simvastatin-induced myopathy: 2014 update.
Ramsey, L B; Johnson, S G; Caudle, K E; Haidar, C E; Voora, D; Wilke, R A; Maxwell, W D; McLeod, H L; Krauss, R M; Roden, D M; Feng, Q; Cooper-DeHoff, R M; Gong, L; Klein, T E; Wadelius, M; Niemi, M.
Afiliação
  • Ramsey LB; Pharmaceutical Sciences Department, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
  • Johnson SG; 1] Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Denver, Colorado, USA [2] Clinical Pharmacy Services, Kaiser Permanente Colorado, Denver, Colorado, USA.
  • Caudle KE; Pharmaceutical Sciences Department, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
  • Haidar CE; Pharmaceutical Sciences Department, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
  • Voora D; Department of Medicine, Duke University, Durham, North Carolina, USA.
  • Wilke RA; 1] IMAGENETICS, Sanford Medical Center, Fargo, North Dakota, USA [2] Department of Medicine, University of North Dakota, Fargo, North Dakota, USA.
  • Maxwell WD; Department of Clinical Pharmacy and Outcomes Sciences, South Carolina College of Pharmacy, Columbia, South Carolina, USA.
  • McLeod HL; Personalized Medicine Institute, Moffitt Cancer Center, Tampa, Florida, USA.
  • Krauss RM; Atherosclerosis Research, Children's Hospital Oakland Research Institute, Oakland, California, USA.
  • Roden DM; 1] Oates Institute for Experimental Therapeutics, Vanderbilt University Medical Center, Nashville, Tennessee, USA [2] Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tennessee, USA.
  • Feng Q; 1] Oates Institute for Experimental Therapeutics, Vanderbilt University Medical Center, Nashville, Tennessee, USA [2] Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tennessee, USA.
  • Cooper-DeHoff RM; Department of Pharmacotherapy and Translational Research, Center for Pharmacogenomics and Division of Cardiovascular Medicine, University of Florida, Gainesville, Florida, USA.
  • Gong L; Department of Genetics, Stanford University, Palo Alto, California, USA.
  • Klein TE; Department of Genetics, Stanford University, Palo Alto, California, USA.
  • Wadelius M; Department of Medical Sciences, Clinical Pharmacology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
  • Niemi M; 1] Department of Clinical Pharmacology, University of Helsinki and HUSLAB, Helsinki University Central Hospital, Helsinki, Finland [2] King Abdulaziz University , Jeddah, Saudi Arabia.
Clin Pharmacol Ther ; 96(4): 423-8, 2014 Oct.
Article em En | MEDLINE | ID: mdl-24918167
ABSTRACT
Simvastatin is among the most commonly used prescription medications for cholesterol reduction. A single coding single-nucleotide polymorphism, rs4149056T>C, in SLCO1B1 increases systemic exposure to simvastatin and the risk of muscle toxicity. We summarize evidence from the literature supporting this association and provide therapeutic recommendations for simvastatin based on SLCO1B1 genotype. This article is an update to the 2012 Clinical Pharmacogenetics Implementation Consortium guideline for SLCO1B1 and simvastatin-induced myopathy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Hidroximetilglutaril-CoA Redutases / Sinvastatina / Transportadores de Ânions Orgânicos / Doenças Musculares Tipo de estudo: Guideline Limite: Humans Idioma: En Revista: Clin Pharmacol Ther Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Hidroximetilglutaril-CoA Redutases / Sinvastatina / Transportadores de Ânions Orgânicos / Doenças Musculares Tipo de estudo: Guideline Limite: Humans Idioma: En Revista: Clin Pharmacol Ther Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos