Comparative study of plasminogen activators in cancers and normal mucosae of human urinary bladder.
Cancer Res
; 49(4): 1067-70, 1989 Feb 15.
Article
em En
| MEDLINE
| ID: mdl-2492205
ABSTRACT
We have developed a highly sensitive sandwich enzyme immunoassay for determination of urokinase-type plasminogen activator (u-PA) and tissue-type plasminogen activator (t-PA) antigen levels in extracts of human tissues. We determined antigen levels of PAs in extracts of 31 primary cancers and 15 normal mucosal tissues of the urinary bladder using this method. U-PA antigen levels in extracts of bladder cancers were significantly higher than those in normal tissues (p less than 0.005). U-PA antigen levels significantly increased as histological grading of malignancy advanced. There was no correlation between t-PA antigen level and malignancy. These results indicate that an increase of u-PA antigen level may be a parameter of malignant transformation and may play an important role in invasiveness of cancer.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bexiga Urinária
/
Neoplasias da Bexiga Urinária
/
Ativadores de Plasminogênio
/
Ativador de Plasminogênio Tipo Uroquinase
/
Biomarcadores Tumorais
/
Ativador de Plasminogênio Tecidual
Tipo de estudo:
Diagnostic_studies
Limite:
Aged
/
Humans
/
Middle aged
Idioma:
En
Revista:
Cancer Res
Ano de publicação:
1989
Tipo de documento:
Article
País de afiliação:
Japão