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Consumption of both low and high (-)-epicatechin apple puree attenuates platelet reactivity and increases plasma concentrations of nitric oxide metabolites: a randomized controlled trial.
Gasper, Amy; Hollands, Wendy; Casgrain, Amelie; Saha, Shikha; Teucher, Birgit; Dainty, Jack R; Venema, Dini P; Hollman, Peter C; Rein, Maarit J; Nelson, Rebecca; Williamson, Gary; Kroon, Paul A.
Afiliação
  • Gasper A; Food and Health Programme, Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, UK.
  • Hollands W; Food and Health Programme, Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, UK.
  • Casgrain A; Food and Health Programme, Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, UK.
  • Saha S; Food and Health Programme, Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, UK.
  • Teucher B; Food and Health Programme, Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, UK.
  • Dainty JR; Food and Health Programme, Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, UK.
  • Venema DP; RIKILT-Institute of Food Safety, Wageningen, The Netherlands.
  • Hollman PC; RIKILT-Institute of Food Safety, Wageningen, The Netherlands.
  • Rein MJ; Nestle Research Center, Vers-chez-les-Blanc, 1000 Lausanne 26, Switzerland.
  • Nelson R; Nestle Research Center, Vers-chez-les-Blanc, 1000 Lausanne 26, Switzerland.
  • Williamson G; Nestle Research Center, Vers-chez-les-Blanc, 1000 Lausanne 26, Switzerland; School of Food Science and Nutrition, University of Leeds, Leeds LS2 9JT, UK.
  • Kroon PA; Food and Health Programme, Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, UK. Electronic address: paul.kroon@ifr.ac.uk.
Arch Biochem Biophys ; 559: 29-37, 2014 Oct 01.
Article em En | MEDLINE | ID: mdl-24929184
We hypothesised that consumption of flavanol-containing apple puree would modulate platelet activity and increase nitric oxide metabolite status, and that high flavanol apple puree would exert a greater effect than low flavanol apple puree. 25 subjects consumed 230 g of apple puree containing 25 and 100mg epicatechin (low and high flavanol apple puree, respectively) and aspirin (75 mg) in random order. Measurements were made at baseline, acutely after treatment (2, 6 and 24 h), and after 14 d of treatment. Low flavanol apple puree significantly attenuated ADP and epinephrine-induced integrin-ß3 expression 2 h and 6 h after consumption and ADP and epinephrine-induced P-selectin expression within 2h of consumption. High flavanol apple puree attenuated epinephrine and ADP-induced integrin-ß3 expression after 2 and 6h. ADP and epinephrine-induced integrin-ß3 expression was significantly attenuated 2, 6 and 24 h after consumption of aspirin, whilst 14 d aspirin consumption attenuated collagen-induced P-selectin expression only. The plasma total nitric oxide metabolite conc. was significantly increased 6h after consumption of both low and high flavanol apple purees. In conclusion, consumption of apple purees containing ⩾25 or 100 mg flavanols transiently attenuated ex vivo integrin-ß3 and P-selectin expression and increased plasma nitric oxide metabolite conc. in healthy subjects, but the effect was not enhanced for the high flavanol apple puree.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plaquetas / Catequina / Malus / Ingestão de Alimentos / Manipulação de Alimentos / Óxido Nítrico Tipo de estudo: Clinical_trials Limite: Adult / Humans / Male / Middle aged Idioma: En Revista: Arch Biochem Biophys Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plaquetas / Catequina / Malus / Ingestão de Alimentos / Manipulação de Alimentos / Óxido Nítrico Tipo de estudo: Clinical_trials Limite: Adult / Humans / Male / Middle aged Idioma: En Revista: Arch Biochem Biophys Ano de publicação: 2014 Tipo de documento: Article