Intravenous salbutamol for childhood asthma: evidence-based medicine?
Arch Dis Child
; 99(9): 873-7, 2014 Sep.
Article
em En
| MEDLINE
| ID: mdl-24938536
ABSTRACT
Intravenous salbutamol is commonly used to treat children with severe asthma unresponsive to inhaled ß2-agonist therapy. However, in this setting, there is little clinical trial data demonstrating its effectiveness. Additionally, there are significant concerns that intravenous salbutamol-dosing recommendations for children with acute asthma are excessive, and unnecessarily raise the potential for adverse reactions, such as lactic acidosis and tachycardia which, by increasing respiratory workload, exacerbate respiratory failure. Here, we review salbutamol clinical pharmacology and toxicology, evidence relating to its use in acute asthma and highlight gaps in the evidence base.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Asma
/
Albuterol
/
Agonistas de Receptores Adrenérgicos beta 2
Tipo de estudo:
Guideline
Limite:
Child
/
Child, preschool
/
Humans
Idioma:
En
Revista:
Arch Dis Child
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Reino Unido