Your browser doesn't support javascript.
loading
The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation.
Franklin, Bernardo S; Bossaller, Lukas; De Nardo, Dominic; Ratter, Jacqueline M; Stutz, Andrea; Engels, Gudrun; Brenker, Christoph; Nordhoff, Mark; Mirandola, Sandra R; Al-Amoudi, Ashraf; Mangan, Matthew S; Zimmer, Sebastian; Monks, Brian G; Fricke, Martin; Schmidt, Reinhold E; Espevik, Terje; Jones, Bernadette; Jarnicki, Andrew G; Hansbro, Philip M; Busto, Patricia; Marshak-Rothstein, Ann; Hornemann, Simone; Aguzzi, Adriano; Kastenmüller, Wolfgang; Latz, Eicke.
Afiliação
  • Franklin BS; Institute of Innate Immunity, University Hospitals, University of Bonn, Bonn, Germany.
  • Bossaller L; 1] Department of Immunology and Rheumatology, Hannover Medical School, Hannover, Germany. [2] Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • De Nardo D; Institute of Innate Immunity, University Hospitals, University of Bonn, Bonn, Germany.
  • Ratter JM; Institute of Innate Immunity, University Hospitals, University of Bonn, Bonn, Germany.
  • Stutz A; Institute of Innate Immunity, University Hospitals, University of Bonn, Bonn, Germany.
  • Engels G; Institute of Innate Immunity, University Hospitals, University of Bonn, Bonn, Germany.
  • Brenker C; German Center for Neurodegenerative Diseases, Bonn, Germany.
  • Nordhoff M; German Center for Neurodegenerative Diseases, Bonn, Germany.
  • Mirandola SR; German Center for Neurodegenerative Diseases, Bonn, Germany.
  • Al-Amoudi A; German Center for Neurodegenerative Diseases, Bonn, Germany.
  • Mangan MS; 1] Institute of Innate Immunity, University Hospitals, University of Bonn, Bonn, Germany. [2] German Center for Neurodegenerative Diseases, Bonn, Germany.
  • Zimmer S; Department of Medicine/Cardiology, University Hospitals, University of Bonn, Bonn, Germany.
  • Monks BG; 1] Institute of Innate Immunity, University Hospitals, University of Bonn, Bonn, Germany. [2] Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Fricke M; Department of Immunology and Rheumatology, Hannover Medical School, Hannover, Germany.
  • Schmidt RE; Department of Immunology and Rheumatology, Hannover Medical School, Hannover, Germany.
  • Espevik T; Center of Molecular Inflammation Research, Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
  • Jones B; Centre for Asthma and Respiratory Disease, The University of Newcastle, Newcastle, Australia.
  • Jarnicki AG; Centre for Asthma and Respiratory Disease, The University of Newcastle, Newcastle, Australia.
  • Hansbro PM; Centre for Asthma and Respiratory Disease, The University of Newcastle, Newcastle, Australia.
  • Busto P; Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Marshak-Rothstein A; Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Hornemann S; University Hospital Zürich, Institute of Neuropathology, Zürich, Switzerland.
  • Aguzzi A; University Hospital Zürich, Institute of Neuropathology, Zürich, Switzerland.
  • Kastenmüller W; Institute of Molecular Medicine and Experimental Immunology, University Hospitals, University of Bonn, Bonn, Germany.
  • Latz E; 1] Institute of Innate Immunity, University Hospitals, University of Bonn, Bonn, Germany. [2] Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA. [3] German Center for Neurodegenerative Diseases, Bonn, Germany. [4] Center of Mo
Nat Immunol ; 15(8): 727-37, 2014 Aug.
Article em En | MEDLINE | ID: mdl-24952505
ABSTRACT
Microbes or danger signals trigger inflammasome sensors, which induce polymerization of the adaptor ASC and the assembly of ASC specks. ASC specks recruit and activate caspase-1, which induces maturation of the cytokine interleukin 1ß (IL-1ß) and pyroptotic cell death. Here we found that after pyroptosis, ASC specks accumulated in the extracellular space, where they promoted further maturation of IL-1ß. In addition, phagocytosis of ASC specks by macrophages induced lysosomal damage and nucleation of soluble ASC, as well as activation of IL-1ß in recipient cells. ASC specks appeared in bodily fluids from inflamed tissues, and autoantibodies to ASC specks developed in patients and mice with autoimmune pathologies. Together these findings reveal extracellular functions of ASC specks and a previously unknown form of cell-to-cell communication.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apoptose / Caspase 1 / Proteínas do Citoesqueleto / Interleucina-1beta / Inflamação Limite: Animals / Humans Idioma: En Revista: Nat Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apoptose / Caspase 1 / Proteínas do Citoesqueleto / Interleucina-1beta / Inflamação Limite: Animals / Humans Idioma: En Revista: Nat Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Alemanha