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Microevolution of Burkholderia pseudomallei during an acute infection.
Limmathurotsakul, Direk; Holden, Matthew T G; Coupland, Paul; Price, Erin P; Chantratita, Narisara; Wuthiekanun, Vanaporn; Amornchai, Premjit; Parkhill, Julian; Peacock, Sharon J.
Afiliação
  • Limmathurotsakul D; Department of Tropical Medicine and Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand direk@tropmedres.ac.
  • Holden MT; The Wellcome Trust Sanger Institute, Cambridge, United Kingdom.
  • Coupland P; The Wellcome Trust Sanger Institute, Cambridge, United Kingdom.
  • Price EP; Global and Tropical Health Division, Menzies School of Health Research, Darwin, Australia.
  • Chantratita N; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
  • Wuthiekanun V; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
  • Amornchai P; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
  • Parkhill J; The Wellcome Trust Sanger Institute, Cambridge, United Kingdom.
  • Peacock SJ; Department of Medicine, Cambridge University, Addenbrooke's Hospital, Cambridge, United Kingdom.
J Clin Microbiol ; 52(9): 3418-21, 2014 Sep.
Article em En | MEDLINE | ID: mdl-24966357
ABSTRACT
We used whole-genome sequencing to evaluate 69 independent colonies of Burkholderia pseudomallei isolated from seven body sites of a patient with acute disseminated melioidosis. Fourteen closely related genotypes were found, providing evidence for the rapid in vivo diversification of B. pseudomallei after inoculation and systemic spread.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Variação Genética / Burkholderia pseudomallei / Evolução Molecular / Melioidose Limite: Adult / Humans / Male Idioma: En Revista: J Clin Microbiol Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Tailândia
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Variação Genética / Burkholderia pseudomallei / Evolução Molecular / Melioidose Limite: Adult / Humans / Male Idioma: En Revista: J Clin Microbiol Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Tailândia