Unprecedent aminophysalin from Physalis angulata.
Steroids
; 88: 60-5, 2014 Oct.
Article
em En
| MEDLINE
| ID: mdl-24973634
ABSTRACT
The 95% ethanol extract of the whole plant of Physalis angulata Linn. afforded one new skeletal physalin named aminophysalin A (1) and one new naturally occurring 5ß-hydroxy-6a-chloro-5,6-dihydrophysalin B (2), together with five known physalins (3-7). Their structures were elucidated through MS, IR, NMR spectroscopy analyses and X-ray crystallography. Aminophysalin A (1) had an absolutely unusual structural feature in the chemistry of physalins with a nitrogen atom. Compounds 1-7 were evaluated for quinone reductase activities in hepa 1c1c7 cells. Physalin H (6) showed strong quinone reductase induction activity with IR (Induction ratio, QR induction activity) value of 3.74±0.02, using 4-bromoflavone as a positive control substance (2.17±0.01, 10 µg/mL), while compounds 1, 2, 3, 5 showed weak quinone reductase induction activity.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esteroides
/
Physalis
Limite:
Humans
Idioma:
En
Revista:
Steroids
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
China