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Oligoclonal band phenotypes in MS differ in their HLA class II association, while specific KIR ligands at HLA class I show association to MS in general.
Gustavsen, Marte W; Viken, Marte K; Celius, Elisabeth G; Berge, Tone; Mero, Inger-Lise; Berg-Hansen, Pål; Aarseth, Jan H; Myhr, Kjell-Morten; Søndergaard, Helle B; Sellebjerg, Finn; Oturai, Annette B; Hillert, Jan; Alfredsson, Lars; Olsson, Tomas; Kockum, Ingrid; Lie, Benedicte A; Harbo, Hanne F.
Afiliação
  • Gustavsen MW; Department of Neurology, Oslo University Hospital, Ullevål, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Electronic address: m.w.gustavsen@medisin.uio.no.
  • Viken MK; Department of Medical Genetics, University of Oslo and Oslo University Hospital, Oslo, Norway; Department of Immunology, Oslo University Hospital and University of Oslo, Oslo, Norway; K.G. Jebsen Inflammation Research Centre, University of Oslo, Oslo, Norway.
  • Celius EG; Department of Neurology, Oslo University Hospital, Ullevål, Oslo, Norway.
  • Berge T; Department of Neurology, Oslo University Hospital, Ullevål, Oslo, Norway.
  • Mero IL; Department of Medical Genetics, University of Oslo and Oslo University Hospital, Oslo, Norway.
  • Berg-Hansen P; Department of Neurology, Oslo University Hospital, Ullevål, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Aarseth JH; The Norwegian Multiple Sclerosis Registry and Biobank, Department of Neurology, Haukeland University Hospital, Bergen, Norway.
  • Myhr KM; The Norwegian Multiple Sclerosis Registry and Biobank, Department of Neurology, Haukeland University Hospital, Bergen, Norway; KG Jebsen Centre for MS-research, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
  • Søndergaard HB; The Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
  • Sellebjerg F; The Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
  • Oturai AB; The Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
  • Hillert J; Department of Clinical Neuroscience, Karolinska Institutet, The Multiple Sclerosis Research Group, Center for Molecular Medicine, L8:00, Stockholm, Sweden.
  • Alfredsson L; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Olsson T; Department of Clinical Neuroscience, Karolinska Institutet, The Neuroimmunology Research Group, Stockholm, Sweden.
  • Kockum I; Department of Clinical Neuroscience, Karolinska Institutet, The Neuroimmunology Research Group, Stockholm, Sweden.
  • Lie BA; Department of Medical Genetics, University of Oslo and Oslo University Hospital, Oslo, Norway; Department of Immunology, Oslo University Hospital and University of Oslo, Oslo, Norway; K.G. Jebsen Inflammation Research Centre, University of Oslo, Oslo, Norway.
  • Harbo HF; Department of Neurology, Oslo University Hospital, Ullevål, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
J Neuroimmunol ; 274(1-2): 174-9, 2014 Sep 15.
Article em En | MEDLINE | ID: mdl-25037176
ABSTRACT
Multiple sclerosis (MS) patients have been reported to have different HLA class II allele profiles depending on oligoclonal bands (OCBs) in the cerebrospinal fluid, but HLA class I alleles and killer cell immunoglobulin-like receptor (KIR) ligands have not been studied. We investigated the association of HLA alleles and KIR ligands according to OCB status in MS patients (n=3876). Specific KIR ligands were associated with patients when compared to controls (n=3148), supporting a role for NK cells in MS pathogenesis. HLA class I alleles and KIR ligands did not differ between OCB phenotypes, but HLA class II associations were convincingly replicated.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esclerose Múltipla Recidivante-Remitente / Bandas Oligoclonais / Receptores KIR2DL1 / Receptores KIR2DL2 / Receptores KIR2DL3 / Cadeias HLA-DRB1 Tipo de estudo: Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: J Neuroimmunol Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esclerose Múltipla Recidivante-Remitente / Bandas Oligoclonais / Receptores KIR2DL1 / Receptores KIR2DL2 / Receptores KIR2DL3 / Cadeias HLA-DRB1 Tipo de estudo: Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: J Neuroimmunol Ano de publicação: 2014 Tipo de documento: Article