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A novel MMP12 locus is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach.
Traylor, Matthew; Mäkelä, Kari-Matti; Kilarski, Laura L; Holliday, Elizabeth G; Devan, William J; Nalls, Mike A; Wiggins, Kerri L; Zhao, Wei; Cheng, Yu-Ching; Achterberg, Sefanja; Malik, Rainer; Sudlow, Cathie; Bevan, Steve; Raitoharju, Emma; Oksala, Niku; Thijs, Vincent; Lemmens, Robin; Lindgren, Arne; Slowik, Agnieszka; Maguire, Jane M; Walters, Matthew; Algra, Ale; Sharma, Pankaj; Attia, John R; Boncoraglio, Giorgio B; Rothwell, Peter M; de Bakker, Paul I W; Bis, Joshua C; Saleheen, Danish; Kittner, Steven J; Mitchell, Braxton D; Rosand, Jonathan; Meschia, James F; Levi, Christopher; Dichgans, Martin; Lehtimäki, Terho; Lewis, Cathryn M; Markus, Hugh S.
Afiliação
  • Traylor M; Stroke and Dementia Research Centre, St George's University of London, London, United Kingdom.
  • Mäkelä KM; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland; School of Medicine, University of Tampere, Tampere, Finland.
  • Kilarski LL; Stroke and Dementia Research Centre, St George's University of London, London, United Kingdom.
  • Holliday EG; Center for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia; Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia.
  • Devan WJ; Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America.
  • Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, United States of America.
  • Wiggins KL; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America.
  • Zhao W; Perelman School of Medicine, Division of Translational Medicine and Human Genetics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
  • Cheng YC; Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America; Research and Development Program, Veterans Affairs Maryland Health Care System, Baltimore, Maryland, United States of America.
  • Achterberg S; Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Malik R; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany.
  • Sudlow C; Division of Clinical Neurosciences and Insititute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.
  • Bevan S; Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
  • Raitoharju E; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland; School of Medicine, University of Tampere, Tampere, Finland.
  • Oksala N; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland; School of Medicine, University of Tampere, Tampere, Finland; Department of Surgery, Tampere University Hospital, Tampere, Finland.
  • Thijs V; KU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology - Laboratory of Neurobiology, Leuven, Belgium; VIB - Vesalius Research Center, Leuven, Belgium; University Hospitals Leuven, Department of Neurology, Leuven, Belgium.
  • Lemmens R; KU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology - Laboratory of Neurobiology, Leuven, Belgium; VIB - Vesalius Research Center, Leuven, Belgium; University Hospitals Leuven, Department of Neurology, Leuven, Belgium.
  • Lindgren A; Department of Clinical Sciences Lund, Neurology, Lund University, Lund, Sweden; Department of Neurology and Rehabilitation Medicine, Skåne University Hospital, Lund, Sweden.
  • Slowik A; Department of Neurology, Jagiellonian University, Krakow, Poland.
  • Maguire JM; Center for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia; Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia; School of Nursing and Midwifery, University of Newcastle, Call
  • Walters M; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom.
  • Algra A; Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Sharma P; Imperial College Cerebrovascular Research Unit (ICCRU), Imperial College London, London, United Kingdom.
  • Attia JR; Center for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia; Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia; Centre for Translational Neuroscience and Mental Health, Unive
  • Boncoraglio GB; Department of Cereberovascular Disease, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Neurologico Carlo Besta, Milan, Italy.
  • Rothwell PM; Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, United Kingdom.
  • de Bakker PI; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands; Department of Medical Genetics, University Medical Cent
  • Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America.
  • Saleheen D; Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America; Center for Non-Communicable Diseases, Karachi, Pakistan.
  • Kittner SJ; Research and Development Program, Veterans Affairs Maryland Health Care System, Baltimore, Maryland, United States of America.
  • Mitchell BD; Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
  • Rosand J; Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America.
  • Meschia JF; Department of Neurology, Mayo Clinic, Jacksonville, Florida, United States of America.
  • Levi C; Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia; Centre for Translational Neuroscience and Mental Health, University of Newcastle, Callaghan, New South Wales, Australia.
  • Dichgans M; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Ludwig-Maximilians-Universität, Munich, Germany.
  • Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland; School of Medicine, University of Tampere, Tampere, Finland.
  • Lewis CM; Department of Medical & Molecular Genetics, King's College London, London, United Kingdom; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, United Kingdom.
  • Markus HS; Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
PLoS Genet ; 10(7): e1004469, 2014 Jul.
Article em En | MEDLINE | ID: mdl-25078452
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença da Artéria Coronariana / Idade de Início / Metaloproteinase 12 da Matriz / Infarto do Miocárdio Tipo de estudo: Risk_factors_studies / Systematic_reviews Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS Genet Assunto da revista: GENETICA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença da Artéria Coronariana / Idade de Início / Metaloproteinase 12 da Matriz / Infarto do Miocárdio Tipo de estudo: Risk_factors_studies / Systematic_reviews Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS Genet Assunto da revista: GENETICA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Reino Unido