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A novel mouse model for the hyper-IgM syndrome: a spontaneous activation-induced cytidine deaminase mutation leading to complete loss of Ig class switching and reduced somatic hypermutation.
Dahlberg, Carin I M; He, Minghui; Visnes, Torkild; Torres, Magda Liz; Cortizas, Elena M; Verdun, Ramiro E; Westerberg, Lisa S; Severinson, Eva; Ström, Lena.
Afiliação
  • Dahlberg CI; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden;
  • He M; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE-106 91 Stockholm, Sweden;
  • Visnes T; Department of Cell and Molecular Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden; and.
  • Torres ML; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden;
  • Cortizas EM; Division of Gerontology and Geriatric Medicine, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136.
  • Verdun RE; Division of Gerontology and Geriatric Medicine, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136.
  • Westerberg LS; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden; lisa.westerberg@ki.se eva.severinson@su.se lena.strom@ki.se.
  • Severinson E; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE-106 91 Stockholm, Sweden; lisa.westerberg@ki.se eva.severinson@su.se lena.strom@ki.se.
  • Ström L; Department of Cell and Molecular Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden; and.
J Immunol ; 193(9): 4732-8, 2014 Nov 01.
Article em En | MEDLINE | ID: mdl-25252954
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Switching de Imunoglobulina / Citidina Desaminase / Hipermutação Somática de Imunoglobulina / Modelos Animais de Doenças / Síndrome de Imunodeficiência com Hiper-IgM / Mutação Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Immunol Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Switching de Imunoglobulina / Citidina Desaminase / Hipermutação Somática de Imunoglobulina / Modelos Animais de Doenças / Síndrome de Imunodeficiência com Hiper-IgM / Mutação Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Immunol Ano de publicação: 2014 Tipo de documento: Article