Regulation of p53 and Rb links the alternative NF-&#954;B pathway to EZH2 expression and cell senescence.

Iannetti, Alessio; Ledoux, Adeline C; Tudhope, Susan J; Sellier, Hélène; Zhao, Bo; Mowla, Sophia; Moore, Adam; Hummerich, Holger; Gewurz, Benjamin E; Cockell, Simon J; Jat, Parmjit S; Willmore, Elaine; Perkins, Neil D

Regulation of p53 and Rb links the alternative NF-κB pathway to EZH2 expression and cell senescence.

Iannetti, Alessio; Ledoux, Adeline C; Tudhope, Susan J; Sellier, Hélène; Zhao, Bo; Mowla, Sophia; Moore, Adam; Hummerich, Holger; Gewurz, Benjamin E; Cockell, Simon J; Jat, Parmjit S; Willmore, Elaine; Perkins, Neil D.

Afiliação

Iannetti A; Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, United Kingdom.
Ledoux AC; Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, United Kingdom.
Tudhope SJ; Northern Institute for Cancer Research, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, United Kingdom.
Sellier H; Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, United Kingdom.
Zhao B; Division of Infectious Disease, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.
Mowla S; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom.
Moore A; Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, United Kingdom.
Hummerich H; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom.
Gewurz BE; Division of Infectious Disease, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.
Cockell SJ; Bioinformatics Support Unit, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, United Kingdom.
Jat PS; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom.
Willmore E; Northern Institute for Cancer Research, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, United Kingdom.
Perkins ND; Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, United Kingdom.

PLoS Genet ; 10(9): e1004642, 2014 Sep.

Article em En | MEDLINE | ID: mdl-25255445

Assuntos

Senescência Celular/genética; NF-kappa B/metabolismo; Complexo Repressor Polycomb 2/genética; Proteína do Retinoblastoma/metabolismo; Transdução de Sinais; Proteína Supressora de Tumor p53/metabolismo; Ligante de CD40/agonistas; Ligante de CD40/metabolismo; Análise por Conglomerados; Proteína Potenciadora do Homólogo 2 de Zeste; Ativação Enzimática; Fibroblastos/metabolismo; Perfilação da Expressão Gênica; Regulação da Expressão Gênica; Humanos; Leucemia Linfocítica Crônica de Células B/genética; Leucemia Linfocítica Crônica de Células B/metabolismo; Modelos Biológicos; Subunidade p52 de NF-kappa B/metabolismo; Complexo Repressor Polycomb 2/metabolismo; Ligação Proteica; Estabilidade Proteica; Interferência de RNA; Espécies Reativas de Oxigênio/metabolismo; Fator de Transcrição RelB/metabolismo; Transcrição Gênica; Transcriptoma

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / NF-kappa B / Proteína Supressora de Tumor p53 / Proteína do Retinoblastoma / Senescência Celular / Complexo Repressor Polycomb 2 Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: PLoS Genet Assunto da revista: GENETICA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Reino Unido

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