Your browser doesn't support javascript.
loading
Molecular characterization of porcine Siglec-10 and analysis of its expression in blood and tissues.
Escalona, Z; Álvarez, B; Uenishi, H; Toki, D; Yuste, M; Revilla, C; del Moral, M Gómez; Alonso, F; Ezquerra, A; Domínguez, J.
Afiliação
  • Escalona Z; Dpto. de Biotecnología, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Ctra de la Coruña Km 7.5, 28040 Madrid, Spain.
  • Álvarez B; Dpto. de Biotecnología, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Ctra de la Coruña Km 7.5, 28040 Madrid, Spain.
  • Uenishi H; National Institute of Agrobiological Sciences (NIAS), 2 Ikenodai, Tsukuba, Ibaraki 305-8602, Japan.
  • Toki D; Institute of Japan Association for Techno-innovation in Agriculture, Forestry and Fisheries, 446-1 Ippaizuka, Kamiyokoba, Tsukuba, Ibaraki 305-0854, Japan.
  • Yuste M; Dpto. de Biotecnología, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Ctra de la Coruña Km 7.5, 28040 Madrid, Spain.
  • Revilla C; Dpto. de Biotecnología, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Ctra de la Coruña Km 7.5, 28040 Madrid, Spain.
  • del Moral MG; Dpto. de Biología Celular y de Inmunología, Facultad de Medicina, Universidad Complutense de Madrid, Avda. Complutense s/n, 28040 Madrid, Spain.
  • Alonso F; Dpto. de Biotecnología, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Ctra de la Coruña Km 7.5, 28040 Madrid, Spain.
  • Ezquerra A; Dpto. de Biotecnología, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Ctra de la Coruña Km 7.5, 28040 Madrid, Spain.
  • Domínguez J; Dpto. de Biotecnología, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Ctra de la Coruña Km 7.5, 28040 Madrid, Spain. Electronic address: juncal@inia.es.
Dev Comp Immunol ; 48(1): 116-23, 2015 Jan.
Article em En | MEDLINE | ID: mdl-25280627
ABSTRACT
Siglecs are sialic acid binding Ig-like proteins involved in the control of leukocyte responses. In this study we describe the characterization of a porcine orthologue of Siglec-10. A cDNA clone was obtained from a porcine library which encodes a protein with sequence homology to human Siglec-10. This cDNA codes for a type I transmembrane protein containing four Ig-like domains, a transmembrane region, and a cytoplasmic tail with three tyrosine-based motifs, including a membrane-proximal Grb2-binding motif, and two ITIM motifs. When expressed on transfected cells, porcine Siglec-10 was able to bind red blood cells in a sialic acid-dependent manner. Monoclonal antibodies were developed against this protein and used to examine its cell and tissue distribution in the pig. Siglec-10 was found to be expressed on blood B cells and B cell areas of the spleen and lymph nodes. A weak expression was also detected on monocytes.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos B / Eritrócitos / Lectinas Semelhantes a Imunoglobulina de Ligação ao Ácido Siálico Limite: Animals Idioma: En Revista: Dev Comp Immunol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Espanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos B / Eritrócitos / Lectinas Semelhantes a Imunoglobulina de Ligação ao Ácido Siálico Limite: Animals Idioma: En Revista: Dev Comp Immunol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Espanha