Accuracy of early detection of colorectal tumours by stool methylation markers: a meta-analysis.
World J Gastroenterol
; 20(38): 14040-50, 2014 Oct 14.
Article
em En
| MEDLINE
| ID: mdl-25320544
ABSTRACT
AIM:
To evaluate the accuracy of methylation of genes in stool samples for diagnosing colorectal tumours.METHODS:
Electronic databases including PubMed, Web of Science, Chinese Journals Full-Text Database and Wanfang Journals Full-Text Database were searched to find relevant original articles about methylated genes to be used in diagnosing colorectal tumours. A quality assessment of diagnostic accuracy studies tool (QADAS) was used to evaluate the quality of the included articles, and the Meta-disc 1.4 and SPSS 13.0 software programs were used for data analysis.RESULTS:
Thirty-seven articles met the inclusion criteria, and 4484 patients were included. The sensitivity and specificity for the detection of colorectal cancer (CRC) were 73% (95%CI 71%-75%) and 92% (95%CI 90%-93%), respectively. For adenoma, the sensitivity and specificity were 51% (95%CI 47%-54%) and 92% (95%CI 90%-93%), respectively. Pooled diagnostic performance of SFRP2 methylation for CRC provided the followingresults:
the sensitivity was 79% (95%CI 75%-82%), the specificity was 93% (95%CI 90%-96%), the diagnostic OR was 47.57 (95%CI 20.08-112.72), the area under the curve was 0.9565. Additionally, the results of accuracy of SFRP2 methylation for detecting colorectal adenomas were as follows sensitivity was 43% (95%CI 38%-49%), specificity was 94% (95%CI 91%-97%), the diagnostic OR was 11.06 (95%CI 5.77-21.18), and the area under the curve was 0.9563.CONCLUSION:
Stool-based DNA testing may be useful for noninvasively diagnosing colorectal tumours and SFRP2 methylation is a promising marker that has great potential in early CRC diagnosis.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinoma
/
Neoplasias Colorretais
/
Biomarcadores Tumorais
/
Adenoma
/
Testes Genéticos
/
Metilação de DNA
/
Detecção Precoce de Câncer
/
Fezes
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
/
Screening_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
World J Gastroenterol
Assunto da revista:
GASTROENTEROLOGIA
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
China