Childhood malnutrition and the intestinal microbiome.
Pediatr Res
; 77(1-2): 256-62, 2015 Jan.
Article
em En
| MEDLINE
| ID: mdl-25356748
ABSTRACT
Malnutrition contributes to almost half of all deaths in children under the age of 5 y, particularly those who live in resource-constrained areas. Those who survive frequently suffer from long-term sequelae including growth failure and neurodevelopmental impairment. Malnutrition is part of a vicious cycle of impaired immunity, recurrent infections, and worsening malnutrition. Recently, alterations in the gut microbiome have also been strongly implicated in childhood malnutrition. It has been suggested that malnutrition may delay the normal development of the gut microbiota in early childhood or force it toward an altered composition that lacks the required functions for healthy growth and/or increases the risk for intestinal inflammation. This review addresses our current understanding of the beneficial contributions of gut microbiota to human nutrition (and conversely the potential role of changes in that community to malnutrition), the process of acquiring an intestinal microbiome, potential influences of malnutrition on the developing microbiota, and the evidence directly linking alterations in the intestinal microbiome to childhood malnutrition. We review recent studies on the association between alterations in the intestinal microbiome and early childhood malnutrition and discuss them in the context of implications for intervention or prevention of the devastation caused by malnutrition.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtornos da Nutrição Infantil
/
Fenômenos Fisiológicos da Nutrição Infantil
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Trato Gastrointestinal
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Diarreia
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Microbiota
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Modelos Biológicos
Limite:
Child
/
Humans
Idioma:
En
Revista:
Pediatr Res
Ano de publicação:
2015
Tipo de documento:
Article