Ca2+ channel blockers prevent seizures induced by a class of K+ channel inhibitors.
Eur J Pharmacol
; 160(1): 173-7, 1989 Jan 24.
Article
em En
| MEDLINE
| ID: mdl-2540990
ABSTRACT
Intracerebroventricular injection into rats of mast-cell degranulating peptide (MCD), dendrotoxin I (DTXI) and 4-aminopyridine (4-AP), three blockers of a subclass of K+ channels, elicited epileptiform wave bursts and convulsions. Three different types of L-type Ca2+ channel inhibitors (+)PN 200-110, a 1,4-dihydropyridine, (-)D888, a phenylalkylamine, and fluspirilene, a diphenylbutylpiperidine, were potent blockers of the convulsant-induced hyperexcitatory effects when they were administered preventively. D-AP5, a N-methyl-D-aspartate antagonist, was active on the 4-AP-induced seizures but was without effect on the MCD- and dendrotoxin-induced seizures.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bloqueadores dos Canais de Cálcio
/
Canais de Potássio
/
Anticonvulsivantes
Limite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Ano de publicação:
1989
Tipo de documento:
Article
País de afiliação:
França