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Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum.
Vaidya, Akhil B; Morrisey, Joanne M; Zhang, Zhongsheng; Das, Sudipta; Daly, Thomas M; Otto, Thomas D; Spillman, Natalie J; Wyvratt, Matthew; Siegl, Peter; Marfurt, Jutta; Wirjanata, Grennady; Sebayang, Boni F; Price, Ric N; Chatterjee, Arnab; Nagle, Advait; Stasiak, Marcin; Charman, Susan A; Angulo-Barturen, Iñigo; Ferrer, Santiago; Belén Jiménez-Díaz, María; Martínez, María Santos; Gamo, Francisco Javier; Avery, Vicky M; Ruecker, Andrea; Delves, Michael; Kirk, Kiaran; Berriman, Matthew; Kortagere, Sandhya; Burrows, Jeremy; Fan, Erkang; Bergman, Lawrence W.
Afiliação
  • Vaidya AB; Department of Microbiology and Immunology, Center for Molecular Parasitology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 190129, USA.
  • Morrisey JM; Department of Microbiology and Immunology, Center for Molecular Parasitology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 190129, USA.
  • Zhang Z; Department of Biochemistry, University of Washington, Box 357350, Seattle, Washington 98195, USA.
  • Das S; Department of Microbiology and Immunology, Center for Molecular Parasitology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 190129, USA.
  • Daly TM; Department of Microbiology and Immunology, Center for Molecular Parasitology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 190129, USA.
  • Otto TD; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB101SA, UK.
  • Spillman NJ; Research School of Biology, The Australian National University, Canberra, Australian Capital Territory 0200, Australia.
  • Wyvratt M; Medicines for Malaria Venture, PO Box 1826, 20Rt de Pr-Bois, Geneva 15 1215, Switzerland.
  • Siegl P; Medicines for Malaria Venture, PO Box 1826, 20Rt de Pr-Bois, Geneva 15 1215, Switzerland.
  • Marfurt J; Division of Global and Tropical Health, Menzies School of Health Research and Charles Darwin University, PO Box 41096, Casuarina, Northern Territory 0811, Australia.
  • Wirjanata G; Division of Global and Tropical Health, Menzies School of Health Research and Charles Darwin University, PO Box 41096, Casuarina, Northern Territory 0811, Australia.
  • Sebayang BF; Eijkman Institute for Molecular Biology, Jl. Diponegoro 69, Jakarta 10430, Indonesia.
  • Price RN; 1] Division of Global and Tropical Health, Menzies School of Health Research and Charles Darwin University, PO Box 41096, Casuarina, Northern Territory 0811, Australia [2] Nuffield Department of Clinical Medicine, Centre for Tropical Medicine, University of Oxford, Oxford OX3 7LJ, UK.
  • Chatterjee A; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, USA.
  • Nagle A; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, USA.
  • Stasiak M; Department of Biochemistry, University of Washington, Box 357350, Seattle, Washington 98195, USA.
  • Charman SA; Center for Drug Candidate Optimisation, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.
  • Angulo-Barturen I; GlaxoSmithKline, Malaria Support Group, Calle Severo Ochoa 2, Tres Cantos 28760, Spain.
  • Ferrer S; GlaxoSmithKline, Malaria Support Group, Calle Severo Ochoa 2, Tres Cantos 28760, Spain.
  • Belén Jiménez-Díaz M; GlaxoSmithKline, Malaria Support Group, Calle Severo Ochoa 2, Tres Cantos 28760, Spain.
  • Martínez MS; GlaxoSmithKline, Malaria Support Group, Calle Severo Ochoa 2, Tres Cantos 28760, Spain.
  • Gamo FJ; GlaxoSmithKline, Malaria Support Group, Calle Severo Ochoa 2, Tres Cantos 28760, Spain.
  • Avery VM; Eskitis Institute, Griffith University, Don Young Road, Nathan, Queensland 4111, Australia.
  • Ruecker A; Department of Life Sciences, South Kensington Campus, Imperial College, London SW7 2AZ, UK.
  • Delves M; Department of Life Sciences, South Kensington Campus, Imperial College, London SW7 2AZ, UK.
  • Kirk K; Research School of Biology, The Australian National University, Canberra, Australian Capital Territory 0200, Australia.
  • Berriman M; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB101SA, UK.
  • Kortagere S; Department of Microbiology and Immunology, Center for Molecular Parasitology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 190129, USA.
  • Burrows J; Medicines for Malaria Venture, PO Box 1826, 20Rt de Pr-Bois, Geneva 15 1215, Switzerland.
  • Fan E; Department of Biochemistry, University of Washington, Box 357350, Seattle, Washington 98195, USA.
  • Bergman LW; Department of Microbiology and Immunology, Center for Molecular Parasitology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 190129, USA.
Nat Commun ; 5: 5521, 2014 Nov 25.
Article em En | MEDLINE | ID: mdl-25422853
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Pirazóis / Sódio / Benzimidazóis / Eritrócitos / Amidas / Malária / Antimaláricos Limite: Female / Humans / Male Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Pirazóis / Sódio / Benzimidazóis / Eritrócitos / Amidas / Malária / Antimaláricos Limite: Female / Humans / Male Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos