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Discovery of the 1,7-diazacarbazole class of inhibitors of checkpoint kinase 1.
Gazzard, Lewis; Appleton, Brent; Chapman, Kerry; Chen, Huifen; Clark, Kevin; Drobnick, Joy; Goodacre, Simon; Halladay, Jason; Lyssikatos, Joseph; Schmidt, Stephen; Sideris, Steve; Wiesmann, Christian; Williams, Karen; Wu, Ping; Yen, Ivana; Malek, Shiva.
Afiliação
  • Gazzard L; Department of Discovery Chemistry, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Appleton B; Department of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Chapman K; Argenta, A Charles River Company, 8-9 Spire Green Centre, Harlow, Essex CM19 5TR, United Kingdom.
  • Chen H; Department of Discovery Chemistry, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Clark K; Department of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Drobnick J; Department of Discovery Chemistry, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Goodacre S; Argenta, A Charles River Company, 8-9 Spire Green Centre, Harlow, Essex CM19 5TR, United Kingdom.
  • Halladay J; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Lyssikatos J; Department of Discovery Chemistry, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Schmidt S; Department of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Sideris S; Department of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Wiesmann C; Department of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Williams K; Argenta, A Charles River Company, 8-9 Spire Green Centre, Harlow, Essex CM19 5TR, United Kingdom.
  • Wu P; Department of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Yen I; Department of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Malek S; Department of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
Bioorg Med Chem Lett ; 24(24): 5704-5709, 2014 Dec 15.
Article em En | MEDLINE | ID: mdl-25453805
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Quinases / Compostos Aza / Carbazóis / Carbolinas / Inibidores de Proteínas Quinases / Descoberta de Drogas Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Quinases / Compostos Aza / Carbazóis / Carbolinas / Inibidores de Proteínas Quinases / Descoberta de Drogas Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos