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A simple novel prognostic model for early stage oral tongue cancer.
Almangush, A; Coletta, R D; Bello, I O; Bitu, C; Keski-Säntti, H; Mäkinen, L K; Kauppila, J H; Pukkila, M; Hagström, J; Laranne, J; Tommola, S; Soini, Y; Kosma, V-M; Koivunen, P; Kowalski, L P; Nieminen, P; Grénman, R; Leivo, I; Salo, T.
Afiliação
  • Almangush A; Department of Pathology, Haartman Institute, University of Helsinki, Helsinki, Finland; Institute of Dentistry, University of Misurata, Misurata, Libya. Electronic address: alhadi.almangush@helsinki.fi.
  • Coletta RD; Department of Oral Diagnosis, School of Dentistry, State University of Campinas, Piracicaba, São Paulo, Brazil.
  • Bello IO; Department of Pathology, Haartman Institute, University of Helsinki, Helsinki, Finland; Department of Oral Medicine and Diagnostic Sciences, King Saud University, Riyadh, Saudi Arabia.
  • Bitu C; Department of Diagnostics and Oral Medicine, Institute of Dentistry, University of Oulu, Oulu, Finland.
  • Keski-Säntti H; Department of Otorhinolaryngology and Head and Neck Surgery, Helsinki University Central Hospital, Helsinki, Finland.
  • Mäkinen LK; Department of Otorhinolaryngology and Head and Neck Surgery, Helsinki University Central Hospital, Helsinki, Finland.
  • Kauppila JH; Departments of Surgery and Pathology, University of Oulu and Oulu University Hospital, Oulu, Finland.
  • Pukkila M; Department of Otorhinolaryngology and Head and Neck Surgery, Kuopio University Hospital, Kuopio, Finland.
  • Hagström J; Department of Pathology, Haartman Institute, University of Helsinki, Helsinki, Finland; Department of Oral Pathology, Institute of Dentistry, University of Helsinki, Helsinki, Finland.
  • Laranne J; Department of Otorhinolaryngology and Head and Neck Surgery, Tampere University Hospital, Tampere, Finland.
  • Tommola S; Department of Pathology, Tampere University Hospital, Tampere, Finland.
  • Soini Y; Department of Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland.
  • Kosma VM; Department of Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland.
  • Koivunen P; Department of Otorhinolaryngology and Head and Neck Surgery, Oulu University Central Hospital, Oulu, Finland.
  • Kowalski LP; Department of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer Centre, São Paulo SP, Brazil.
  • Nieminen P; Department of Medical Informatics and Statistics, University of Oulu, Oulu, Finland.
  • Grénman R; Department of Otorhinolaryngology - Head and Neck Surgery, Turku University Hospital, University of Turku, Turku, Finland.
  • Leivo I; Department of Pathology, Haartman Institute, University of Helsinki, Helsinki, Finland; Department of Pathology, University of Turku, Turku, Finland.
  • Salo T; Department of Diagnostics and Oral Medicine, Institute of Dentistry, University of Oulu, Oulu, Finland; Department of Diagnostics and Oral Medicine, Oulu University Hospital and Medical Research Centre, Oulu, Finland; Institute of Dentistry, University of Helsinki, Helsinki, Finland.
Int J Oral Maxillofac Surg ; 44(2): 143-50, 2015 Feb.
Article em En | MEDLINE | ID: mdl-25457829
ABSTRACT
The prognostication of patient outcome is one of the greatest challenges in the management of early stage oral tongue squamous cell carcinoma (OTSCC). This study introduces a simple histopathological model for the prognostication of survival in patients with early OTSCC. A total of 311 cases (from Finland and Brazil) with clinically evaluated early stage OTSCC (cT1-T2cN0cM0) were included in this multicentre retrospective study. Tumour budding (B) and depth of invasion (D) were scored on haematoxylin-eosin-stained cancer slides. The cut-off point for tumour budding was set at 5 buds (low <5; high ≥5) and for depth of invasion at 4mm (low <4mm; high ≥4mm). The scores of B and D were combined into one model the BD predictive model. On multivariate analysis, a high risk score (BD score 2) correlated significantly with loco-regional recurrence (P=0.033) and death due to OTSCC (P<0.001) in early stage OTSCC. The new BD model is a promising prognostic tool to identify those patients with aggressive cases of early stage OTSCC who might benefit from multimodality treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Língua / Carcinoma de Células Escamosas Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Child / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil / Europa Idioma: En Revista: Int J Oral Maxillofac Surg Assunto da revista: ODONTOLOGIA Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Língua / Carcinoma de Células Escamosas Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Child / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil / Europa Idioma: En Revista: Int J Oral Maxillofac Surg Assunto da revista: ODONTOLOGIA Ano de publicação: 2015 Tipo de documento: Article