Combination regimens of radiation therapy and therapeutic cancer vaccines: mechanisms and opportunities.
Semin Radiat Oncol
; 25(1): 46-53, 2015 Jan.
Article
em En
| MEDLINE
| ID: mdl-25481266
ABSTRACT
Radiation therapy (RT) is widely used with curative or palliative intent in the clinical management of multiple cancers. Although mainly aimed at direct tumor cell killing, mounting evidence suggests that radiation can alter the tumor to become an immunostimulatory milieu. Data suggest that the immunogenic effects of radiation can be exploited to promote synergistic antitumor effects in combination with immunotherapeutic agents. We review concepts associated with the immunogenic consequences of RT and highlight how preclinical findings are translating into clinical benefit for patients receiving combination regimens of RT and therapeutic cancer vaccines.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vacinas Anticâncer
/
Neoplasias
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Semin Radiat Oncol
Assunto da revista:
NEOPLASIAS
/
RADIOLOGIA
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Gabão