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Signalling through sIgA on a novel murine B lymphoma.
Monroe, J G; Blank, K J; Owen, C S; Sykes, N.
Afiliação
  • Monroe JG; Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104.
Mol Immunol ; 26(7): 593-9, 1989 Jul.
Article em En | MEDLINE | ID: mdl-2550816
ABSTRACT
A novel murine B lymphoma expressing membrane-associated IgA was isolated and used to compare mechanisms of signal transduction by sIgM and sIgA. Like other isotypes so far studied, crosslinking of sIgA by anti-immunoglobulin antibodies stimulates hydrolysis of inositol phospholipids and causes elevation of intracellular free calcium. Furthermore, signals generated through sIgA are coupled to elevation of c-fos proto-oncogene expression. Coupling appears to be through the protein kinase C rather than through the Ca2+ component of sIg signalling as phorbol diester, but the Ca2+ ionophore cannot mediate this effect. Thus these results, coupled with those from earlier studies, show that early signal transduction through surface immunoglobulin appears to be similar regardless of the particular isotype involved in binding ligand.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunoglobulina A / Receptores de Antígenos de Linfócitos B / Transdução de Sinais / Linfoma / Anticorpos Antineoplásicos Limite: Animals Idioma: En Revista: Mol Immunol Ano de publicação: 1989 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunoglobulina A / Receptores de Antígenos de Linfócitos B / Transdução de Sinais / Linfoma / Anticorpos Antineoplásicos Limite: Animals Idioma: En Revista: Mol Immunol Ano de publicação: 1989 Tipo de documento: Article