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Antiretroviral Pre-Exposure Prophylaxis Does Not Enhance Immune Responses to HIV in Exposed but Uninfected Persons.
Pattacini, Laura; Murnane, Pamela M; Baeten, Jared M; Fluharty, Tayler R; Thomas, Katherine K; Bukusi, Elizabeth; Katabira, Elly; Mugo, Nelly; Donnell, Deborah; Lingappa, Jairam R; Celum, Connie; Marzinke, Mark; McElrath, M Juliana; Lund, Jennifer M.
Afiliação
  • Pattacini L; Vaccine and Infectious Disease Division.
  • Murnane PM; Department of Global Health Department of Epidemiology.
  • Baeten JM; Department of Global Health Department of Epidemiology Department of Medicine.
  • Fluharty TR; Vaccine and Infectious Disease Division.
  • Thomas KK; Department of Global Health.
  • Bukusi E; Department of Global Health Department of Obstetrics and Gynecology Centre for Microbiology Research.
  • Katabira E; Department of Medicine, Makerere University, Kampala, Uganda.
  • Mugo N; Department of Global Health Centre for Clinical Research, Kenya Medical Research Institute, Nairobi.
  • Donnell D; Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center Department of Global Health.
  • Lingappa JR; Department of Global Health Department of Medicine Department of Pediatrics, University of Washington, Seattle.
  • Celum C; Department of Global Health Department of Epidemiology Department of Medicine.
  • Marzinke M; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
  • McElrath MJ; Vaccine and Infectious Disease Division Department of Global Health Department of Medicine.
  • Lund JM; Vaccine and Infectious Disease Division Department of Global Health.
J Infect Dis ; 211(12): 1943-52, 2015 Jun 15.
Article em En | MEDLINE | ID: mdl-25520426
BACKGROUND: Antiretroviral preexposure prophylaxis (PrEP), using daily oral combination tenofovir disoproxil fumarate plus emtricitabine, is an effective human immunodeficiency virus (HIV) prevention strategy for populations at high risk of HIV acquisition. Although the primary mode of action for the protective effect of PrEP is probably direct antiviral activity, nonhuman primate studies suggest that PrEP may also allow for development of HIV-specific immune responses, hypothesized to result from aborted HIV infections providing a source of immunologic priming. We sought to evaluate whether PrEP affects the development of HIV-specific immune response in humans. METHODS AND RESULTS: Within a PrEP clinical trial among high-risk heterosexual African men and women, we detected HIV-specific CD4(+) and CD8(+) peripheral blood T-cell responses in 10%-20% of 247 subjects evaluated. The response rate and magnitude of T-cell responses did not vary significantly between those assigned PrEP versus placebo, and no significant difference between those assigned PrEP and placebo was observed in measures of innate immune function. CONCLUSIONS: We found no evidence to support the hypothesis that PrEP alters either the frequency or magnitude of HIV-specific immune responses in HIV-1-exposed seronegative individuals. These results suggest that PrEP is unlikely to serve as an immunologic prime to aid protection by a putative HIV vaccine.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T CD4-Positivos / HIV-1 / Linfócitos T CD8-Positivos / Quimioprevenção / Antirretrovirais / Profilaxia Pré-Exposição Tipo de estudo: Clinical_trials Limite: Adult / Animals / Female / Humans / Male País/Região como assunto: Africa Idioma: En Revista: J Infect Dis Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T CD4-Positivos / HIV-1 / Linfócitos T CD8-Positivos / Quimioprevenção / Antirretrovirais / Profilaxia Pré-Exposição Tipo de estudo: Clinical_trials Limite: Adult / Animals / Female / Humans / Male País/Região como assunto: Africa Idioma: En Revista: J Infect Dis Ano de publicação: 2015 Tipo de documento: Article