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Persistent cerebrovascular damage after stroke in type two diabetic rats measured by magnetic resonance imaging.
Ding, Guangliang; Yan, Tao; Chen, Jieli; Chopp, Michael; Li, Lian; Li, Qingjiang; Cui, Chengcheng; Ning, Ruizhuo; Jiang, Quan.
Afiliação
  • Ding G; From the Department of Neurology, Henry Ford Hospital, Detroit, MI (G.D., T.Y., J.C., M.C., L.L., Q.L., C.C., R.N., Q.J.); and Department of Physics, Oakland University, Rochester, MI (M.C.).
  • Yan T; From the Department of Neurology, Henry Ford Hospital, Detroit, MI (G.D., T.Y., J.C., M.C., L.L., Q.L., C.C., R.N., Q.J.); and Department of Physics, Oakland University, Rochester, MI (M.C.).
  • Chen J; From the Department of Neurology, Henry Ford Hospital, Detroit, MI (G.D., T.Y., J.C., M.C., L.L., Q.L., C.C., R.N., Q.J.); and Department of Physics, Oakland University, Rochester, MI (M.C.).
  • Chopp M; From the Department of Neurology, Henry Ford Hospital, Detroit, MI (G.D., T.Y., J.C., M.C., L.L., Q.L., C.C., R.N., Q.J.); and Department of Physics, Oakland University, Rochester, MI (M.C.).
  • Li L; From the Department of Neurology, Henry Ford Hospital, Detroit, MI (G.D., T.Y., J.C., M.C., L.L., Q.L., C.C., R.N., Q.J.); and Department of Physics, Oakland University, Rochester, MI (M.C.).
  • Li Q; From the Department of Neurology, Henry Ford Hospital, Detroit, MI (G.D., T.Y., J.C., M.C., L.L., Q.L., C.C., R.N., Q.J.); and Department of Physics, Oakland University, Rochester, MI (M.C.).
  • Cui C; From the Department of Neurology, Henry Ford Hospital, Detroit, MI (G.D., T.Y., J.C., M.C., L.L., Q.L., C.C., R.N., Q.J.); and Department of Physics, Oakland University, Rochester, MI (M.C.).
  • Ning R; From the Department of Neurology, Henry Ford Hospital, Detroit, MI (G.D., T.Y., J.C., M.C., L.L., Q.L., C.C., R.N., Q.J.); and Department of Physics, Oakland University, Rochester, MI (M.C.).
  • Jiang Q; From the Department of Neurology, Henry Ford Hospital, Detroit, MI (G.D., T.Y., J.C., M.C., L.L., Q.L., C.C., R.N., Q.J.); and Department of Physics, Oakland University, Rochester, MI (M.C.). qjiang1@hfhs.org.
Stroke ; 46(2): 507-12, 2015 Feb.
Article em En | MEDLINE | ID: mdl-25523056
ABSTRACT
BACKGROUND AND

PURPOSE:

Diabetes mellitus is a disease with vascular components. Consequently, the blood-brain barrier disruption after stroke may differ between diabetic and nondiabetic animals. However, few studies have documented the longitudinal blood-brain barrier disruption afte stroke in diabetic animals. In this study, using MRI, we noninvasively evaluated the blood-brain barrier damage after middle cerebral artery occlusion in diabetic and nondiabetic rats.

METHODS:

Type 2 diabetes mellitus (T2DM) was induced in adult male Wistar rats by administration of a high-fat diet in combination with a single intraperitoneal injection (35 mg/kg) of streptozotocin. T2DM rats (n=9) and nondiabetic wild-type (WT) rats (n=9) were subjected to middle cerebral artery occlusion for 2 hours using the filament model. MRI was performed 1 day and then weekly for 5 weeks after middle cerebral artery occlusion for all rats.

RESULTS:

The ischemic lesion volumes after stroke as measured using T2 maps were not significantly different between the T2DM and WT rats. Compared with the WT rats, the volumes of blood-brain barrier disruption evaluated using contrast-enhanced T1-weighted imaging with gadolinium-diethylenetriamine penta-acetic acid and the cerebral hemorrhagic volumes measured with susceptibility-weighted imaging were significantly (P<0.05) larger in the T2DM rats from 1 to 5 weeks after stroke; values of diffusion fractional anisotropy were significantly lower in T2DM rats (P<0.03) than in WT rats after stroke. These MRI measurements were consistent with histological data.

CONCLUSIONS:

Using MRI, T2-weighted imaging did not detect significant differences of the ischemic lesion volumes between T2DM and WT rats. In contrast to the WT rats, however, contrast-enhanced T1-weighted imaging and susceptibility-weighted imaging identified much more severe ischemic vascular damage, whereas fractional anisotropy demonstrated lower axonal density in the T2DM rats after stroke.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imageamento por Ressonância Magnética / Transtornos Cerebrovasculares / Acidente Vascular Cerebral / Diabetes Mellitus Tipo 2 Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Stroke Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imageamento por Ressonância Magnética / Transtornos Cerebrovasculares / Acidente Vascular Cerebral / Diabetes Mellitus Tipo 2 Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Stroke Ano de publicação: 2015 Tipo de documento: Article