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pH-dependent binding engineering reveals an FcRn affinity threshold that governs IgG recycling.
Borrok, M Jack; Wu, Yanli; Beyaz, Nurten; Yu, Xiang-Qing; Oganesyan, Vaheh; Dall'Acqua, William F; Tsui, Ping.
Afiliação
  • Borrok MJ; From the Departments of Antibody Discovery and Protein Engineering and.
  • Wu Y; From the Departments of Antibody Discovery and Protein Engineering and.
  • Beyaz N; From the Departments of Antibody Discovery and Protein Engineering and.
  • Yu XQ; Clinical Pharmacology and Drug Metabolism and Pharmacokinetics, MedImmune, Inc., Gaithersburg, Maryland 20878.
  • Oganesyan V; From the Departments of Antibody Discovery and Protein Engineering and.
  • Dall'Acqua WF; From the Departments of Antibody Discovery and Protein Engineering and dallacquaw@medimmune.com.
  • Tsui P; From the Departments of Antibody Discovery and Protein Engineering and tsuip@medimmune.com.
J Biol Chem ; 290(7): 4282-90, 2015 Feb 13.
Article em En | MEDLINE | ID: mdl-25538249

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunoglobulina G / Receptores Fc / Antígenos de Histocompatibilidade Classe I / Engenharia de Proteínas / Anticorpos Monoclonais Limite: Animals / Female / Humans / Male Idioma: En Revista: J Biol Chem Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunoglobulina G / Receptores Fc / Antígenos de Histocompatibilidade Classe I / Engenharia de Proteínas / Anticorpos Monoclonais Limite: Animals / Female / Humans / Male Idioma: En Revista: J Biol Chem Ano de publicação: 2015 Tipo de documento: Article