Ovarian preservation in young women with endometrial cancer of endometrioid histology.
Acta Obstet Gynecol Scand
; 94(4): 430-4, 2015 Apr.
Article
em En
| MEDLINE
| ID: mdl-25603833
ABSTRACT
OBJECTIVE:
To clarify the frequency and risk factors of ovarian metastasis in women with endometrial cancer of endometrioid histology.DESIGN:
Retrospective observational study.SETTING:
University of the Ryukyus Japan 1990-2011. POPULATION Eighty-eight women ≤ 45 years of age with endometrial cancer of only endometrioid histology.METHODS:
Clinicopathological factors from the medical records were used. Fisher's exact test and logistic regression analysis were used to analyze predictive factors for ovarian metastasis. MAIN OUTCOMEMEASURES:
Risk factors of ovarian malignancy.RESULTS:
All women underwent total abdominal hysterectomy, bilateral salpingo-oophorectomy and lymph node dissection. The median age was 39 years, and FIGO stage distributions were stage I, 63 (71.6%) women; stage II, 14 (15.9%) women; and stage III, 11 (12.5%) women. Pathologically, ovarian metastasis was observed in four (4.5%) women. Only lymph node metastasis was a significant predictive factor for ovarian metastasis (p = 0.0038), and deep myometrial invasion was the only significant factor (p = 0.0085) for the prediction of lymph node metastasis. No ovarian malignancy was found in 72 women with invasion ≤ 50% myometrial depth and no enlargement of the ovaries. We observed ovarian metastasis in two (14.3%) of 14 women with deep myometrial invasion without ovarian tumor.CONCLUSION:
Ovarian preservation surgery might be considered in endometrial cancer of endometrioid histology with ≤ 50% myometrial depth invasion with no ovarian mass after taking into account family history.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ovarianas
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Ovariectomia
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Neoplasias do Endométrio
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Carcinoma Endometrioide
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Salpingectomia
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Histerectomia
Tipo de estudo:
Etiology_studies
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Evaluation_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
Acta Obstet Gynecol Scand
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Japão