Antiviral properties from plants of the Mediterranean flora.
Nat Prod Res
; 29(22): 2065-70, 2015.
Article
em En
| MEDLINE
| ID: mdl-25613403
ABSTRACT
Natural products are a successful source in drug discovery, playing a significant role in maintaining human health. We investigated the in vitro cytotoxicity and antiviral activity of extracts from 18 traditionally used Mediterranean plants. Noteworthy antiviral activity was found in the extract obtained from the branches of Daphne gnidium L. against human immunodeficiency virus type-1 (EC50 = 0.08 µg/mL) and coxsackievirus B5 (EC50 = 0.10 µg/mL). Other relevant activities were found against BVDV, YFV, Sb-1, RSV and HSV-1. Interestingly, extracts from Artemisia arborescens L. and Rubus ulmifolius Schott, as well as those from D. gnidium L., showed activities against two different viruses. This extensive antiviral screening allowed us to identify attractive activities, offering opportunities to develop lead compounds with a great pharmaceutical potential.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
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Extratos Vegetais
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Artemisia
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Daphne
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Rubus
País/Região como assunto:
Europa
Idioma:
En
Revista:
Nat Prod Res
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Itália