Fentanyl produces cholinergically-mediated analeptic and EEG arousal effects in rats.
Neuropharmacology
; 28(5): 481-6, 1989 May.
Article
em En
| MEDLINE
| ID: mdl-2566949
ABSTRACT
Fentanyl (20 micrograms/kg i.p.), administered to naltrexone-pretreated, pentobarbital-anesthetized rats, produced a shortening of the duration of narcosis. This analeptic effect was blocked by atropine, but not by methylatropine, indicating that a central cholinergic mechanism was involved. Fentanyl also increased sodium-dependent high affinity uptake of choline activity in the hippocampus and cortex that had been depressed by the barbiturate. Injection of 0.8 ng of fentanyl into the pontis oralis in the pontine reticular formation also produced analepsis in naltrexone-pretreated, pentobarbitalized rats. Hippocampal EEG recordings also showed the appearance of cholinergically-mediated theta activity, which was indicative of arousal activity in the hippocampus. These results suggest that fentanyl, in addition to possessing potent opiate activity, also activates a nonopioid-mediated central cholinergic arousal system.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sistema Nervoso Parassimpático
/
Fentanila
/
Eletroencefalografia
/
Estimulantes do Sistema Nervoso Central
Limite:
Animals
Idioma:
En
Revista:
Neuropharmacology
Ano de publicação:
1989
Tipo de documento:
Article