Evaluation of Immune Restoration Potential of PD-1 Blockers.
J Immunoassay Immunochem
; 36(6): 567-72, 2015.
Article
em En
| MEDLINE
| ID: mdl-25714590
ABSTRACT
The programmed death 1 (PD-1) receptor and its primary ligand (PD-L1) have crucial roles in tumor-induced immune suppression. PD-1/PD-L1 blockers are designed to restore the immune system and induce potent antitumor effects. In this study we established a direct and reliable method to evaluate the immune restoration potential of human PD-1 blockers. We found anti-human PD-1 antibody could reverse PD-L1 induced suppression of human CD3+ cells proliferation and IL-2 production. This method is suitable for all kinds of PD-1 blockers including antibodies and chemical drugs. This function assay could be easily applied and provide valuable information for drug development.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leucócitos Mononucleares
/
Receptor de Morte Celular Programada 1
/
Anticorpos
Tipo de estudo:
Evaluation_studies
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Immunoassay Immunochem
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
China