N-methyl-D-aspartate receptors and Alzheimer's disease.
Neurobiol Aging
; 10(5): 603-5; discussion 618-20, 1989.
Article
em En
| MEDLINE
| ID: mdl-2572983
ABSTRACT
The results of several studies now suggest that the density of N-methyl-D-aspartate (NMDA) receptors is maintained in many Alzheimer's disease (AD) cases, although loss of these receptors can occur in specific regions as a consequence of severe neuronal loss. Recent findings demonstrate that there are at least two subtypes of the NMDA receptor which are allosterically regulated. To determine the status of the NMDA receptor in AD, studies are required which will examine the activation state of the NMDA receptor and the properties of subtypes in relation to neuronal density and structure.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de Neurotransmissores
/
Doença de Alzheimer
/
Glutamatos
Limite:
Humans
Idioma:
En
Revista:
Neurobiol Aging
Ano de publicação:
1989
Tipo de documento:
Article