A new DNA marker tightly linked to the fragile X locus (FRAXA).
Science
; 246(4935): 1298-300, 1989 Dec 08.
Article
em En
| MEDLINE
| ID: mdl-2573953
ABSTRACT
The fragile X syndrome is the most common cause of familial mental retardation. Genetic counseling and gene isolation are hampered by a lack of DNA markers close to the disease locus. Two somatic cell hybrids that each contain a human X chromosome with a breakpoint close to the fragile X locus have been characterized. A new DNA marker (DXS296) lies between the chromosome breakpoints and is the closest marker to the fragile X locus yet reported. The Hunter syndrome gene, which causes iduronate sulfatase deficiency, is located at the X chromosome breakpoint that is distal to this new marker, thus localizing the Hunter gene distal to the fragile X locus.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aberrações dos Cromossomos Sexuais
/
Marcadores Genéticos
/
Síndrome do Cromossomo X Frágil
/
Ligação Genética
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
1989
Tipo de documento:
Article
País de afiliação:
Austrália