Hydroxyapatite-based materials of marine origin: a bioactivity and sintering study.
Mater Sci Eng C Mater Biol Appl
; 51: 309-15, 2015 Jun.
Article
em En
| MEDLINE
| ID: mdl-25842140
ABSTRACT
Single phase hydroxyapatite (HAp) and biphasic material hydroxyapatite/ß-tricalcium phosphate (HAp/ß-TCP) were obtained from a marine source (Atlantic cod fish bones). Here we report a study on the biological properties of these materials, including cytotoxicity, bioactivity and haemocompatibility. Results showed that the materials are not cytotoxic, neither in their powder nor in pellet form; indeed growth of Saos-2 cells was comparable to that of commercial. The haemolysis rate was lower than 2%; hence the materials can be classified as non-haemolytic. Moreover, when immersed in Simulated Body Fluid (SBF), crystal formation was observed on the surface of both materials. The sintering behaviour of the samples was also studied; both powders showed very high sinterability (density higher than 95% of the theoretical value). Overall, these results confirm the suitability of these materials for biomedical applications.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Produtos Biológicos
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Osso e Ossos
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Substitutos Ósseos
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Gadiformes
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Hidroxiapatitas
Limite:
Animals
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Humans
Idioma:
En
Revista:
Mater Sci Eng C Mater Biol Appl
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Portugal