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Pharmacokinetics of dolutegravir in a premature neonate after HIV treatment intensification during pregnancy.
Pain, J B; Lê, M P; Caseris, M; Amiel, C; Lassel, L; Charpentier, C; Desnoyer, A; Farnoux, C; Pialoux, G; Descamps, D; Peytavin, G.
Afiliação
  • Pain JB; AP-HP, Clinical Pharmacology Department, Bichat Hospital, Paris, France.
  • Lê MP; AP-HP, Clinical Pharmacology Department, Bichat Hospital, Paris, France minh.le@bch.aphp.fr.
  • Caseris M; AP-HP, General Pediatrics, Robert Debré Hospital, Paris, France.
  • Amiel C; AP-HP, Virology Department, Tenon Hospital, Paris, France AP-HP, UPMC Université Paris 06, UMRS CR7, Inserm U1135, Paris, France.
  • Lassel L; AP-HP, Infectious Diseases Unit, Tenon Hospital, Paris, France.
  • Charpentier C; AP-HP, Virology Department, Bichat Hospital, Paris, France IAME, UMR 1137, Université Paris Diderot, Sorbonne Paris Cité and UMR 1137, INSERM, Paris, France.
  • Desnoyer A; AP-HP, Clinical Pharmacology Department, Bichat Hospital, Paris, France.
  • Farnoux C; AP-HP, Neonatology Department, Robert Debré Hospital, Paris, France.
  • Pialoux G; AP-HP, UPMC Université Paris 06, UMRS CR7, Inserm U1135, Paris, France.
  • Descamps D; AP-HP, Virology Department, Bichat Hospital, Paris, France IAME, UMR 1137, Université Paris Diderot, Sorbonne Paris Cité and UMR 1137, INSERM, Paris, France.
  • Peytavin G; AP-HP, Clinical Pharmacology Department, Bichat Hospital, Paris, France IAME, UMR 1137, Université Paris Diderot, Sorbonne Paris Cité and UMR 1137, INSERM, Paris, France.
Antimicrob Agents Chemother ; 59(6): 3660-2, 2015.
Article em En | MEDLINE | ID: mdl-25845873
ABSTRACT
We describe the pharmacokinetics of dolutegravir (DTG) in a premature neonate after maternal intensification of an antiretroviral (ARV) regimen by adding DTG. During the last 2 weeks of pregnancy, the ARV was tenofovir-emtricitabine, atazanavir-ritonavir, and DTG (50 mg once daily). From the interaction between atazanavir and DTG via CYP3A4 and UGT1A1 and placental efflux transporter inhibition and considering the infant's probable enzymatic immaturity, the DTG elimination half-life was estimated to be 4-fold longer in neonates than in adults.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fármacos Anti-HIV / Compostos Heterocíclicos com 3 Anéis Limite: Adult / Female / Humans / Male / Newborn / Pregnancy Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2015 Tipo de documento: Article País de afiliação: França
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fármacos Anti-HIV / Compostos Heterocíclicos com 3 Anéis Limite: Adult / Female / Humans / Male / Newborn / Pregnancy Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2015 Tipo de documento: Article País de afiliação: França