Vertebral compression fractures may increase mortality in male patients with chronic obstructive pulmonary disease.
Int J Tuberc Lung Dis
; 19(5): 603-9, 2015 May.
Article
em En
| MEDLINE
| ID: mdl-25868031
ABSTRACT
BACKGROUND:
Vertebral compression fracture (VCF) is frequent in chronic obstructive pulmonary disease (COPD) patients. However, little is known about whether VCF affects mortality in COPD patients.OBJECTIVE:
To investigate whether VCFs might increase death in COPD patients.METHODS:
In this retrospective cohort study, we enrolled 254 COPD patients with a recent history of hospitalisation due to respiratory problems. Patients were assessed for VCF using quantitative morphometric analyses of lateral chest radiographs; 211 patients received follow-up examinations for 2 years.RESULTS:
Of the 211 COPD patients analysed, 60 (28.4%) had VCF at enrolment. During the follow-up period, 33/60 (55.0%) patients with and 46/151 patients (30.5%) without VCF died (P = 0.003, log-rank test). Cox proportional hazard analysis revealed that VCF is an independent risk factor for death after adjusting for age, sex, body mass index, smoking, dyspnoea scale, forced expiratory volume in 1 sec (FEV1) and comorbidities (hazard ratio for VCF = 1.79, 95%CI 1.11-2.89, P = 0.02).CONCLUSION:
VCF might be an independent risk factor for death in male COPD patients.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vértebras Torácicas
/
Causas de Morte
/
Fraturas da Coluna Vertebral
/
Doença Pulmonar Obstrutiva Crônica
/
Fraturas por Compressão
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Aged80
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Int J Tuberc Lung Dis
Ano de publicação:
2015
Tipo de documento:
Article