Polyclonal gammopathy after BKV infection in HSCT recipient: a novel trigger for plasma cells replication?
Virol J
; 12: 23, 2015 Feb 13.
Article
em En
| MEDLINE
| ID: mdl-25886491
ABSTRACT
BACKGROUND:
BK polyomavirus infects most of the general population. However, its clinical manifestations are almost exclusively seen in immunocompromised patients, particularly in kidney and hematopoietic stem cell transplantation recipients. CASE PRESENTATION A 15-y-old female suffering from common B-cell acute lymphoblastic leukaemia underwent hematopoietic stem cell transplantation. The patient had reactivation of BKPyV infection and developed an haemorrhagic cystitis. Three months after transplant, BKPyV viremia and viruria increased and she developed a severe nephropathy associated to a polyclonal gammopathy with high levels of isolated IgM.CONCLUSION:
This case report describes a rare and unexpected polyclonal gammopathy developed during a polyomavirus-associated nephropathy confirmed by immunohistochemical and laboratory analyses.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plasmócitos
/
Leucemia de Células B
/
Vírus BK
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Transplante de Células-Tronco Hematopoéticas
/
Infecções por Polyomavirus
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
/
Nefropatias
/
Anticorpos Antivirais
Tipo de estudo:
Etiology_studies
Limite:
Adolescent
/
Female
/
Humans
Idioma:
En
Revista:
Virol J
Assunto da revista:
VIROLOGIA
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Itália