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Afatinib versus methotrexate as second-line treatment in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck progressing on or after platinum-based therapy (LUX-Head & Neck 1): an open-label, randomised phase 3 trial.
Machiels, Jean-Pascal H; Haddad, Robert I; Fayette, Jérôme; Licitra, Lisa F; Tahara, Makoto; Vermorken, Jan B; Clement, Paul M; Gauler, Thomas; Cupissol, Didier; Grau, Juan José; Guigay, Joël; Caponigro, Francesco; de Castro, Gilberto; de Souza Viana, Luciano; Keilholz, Ulrich; Del Campo, Joseph M; Cong, Xiuyu Julie; Ehrnrooth, Eva; Cohen, Ezra E W.
Afiliação
  • Machiels JP; Institut Roi Albert II, Service d'Oncologie Médicale, Cliniques Universitaires Saint-Luc and Institut de Recherche Clinique et Expérimentale (Pole MIRO), Université Catholique de Louvain, Brussels. Electronic address: jean-pascal.machiels@uclouvain.be.
  • Haddad RI; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School and Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
  • Fayette J; Léon Bérard Center and Hospices Civils de Lyon, University of Lyon, Lyon, France.
  • Licitra LF; Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
  • Tahara M; National Cancer Center Hospital East, Kashiwa, Japan.
  • Vermorken JB; Antwerp University Hospital, Edegem, Belgium.
  • Clement PM; Department of Oncology, KU Leuven, Leuven, Belgium.
  • Gauler T; West German Cancer Center, University Hospital Essen, Essen, Germany.
  • Cupissol D; Institut du Cancer de Montpellier Val d'Aurelle, Montpellier, France.
  • Grau JJ; Hospital Clínic de Barcelona, University of Barcelona, Spain.
  • Guigay J; Gustave Roussy, Villejuif and Centre Antoine Lacassagne, Nice, France.
  • Caponigro F; Division of Head and Neck Medical Oncology, Istituto Nazionale Tumori "Fondazione G Pascale"-IRCCS, Naples, Italy.
  • de Castro G; Instituto do Câncer do Estado de São Paulo, Brazil.
  • de Souza Viana L; Hospital de Câncer de Barretos, São Paulo, Brazil.
  • Keilholz U; Charité Comprehensive Cancer Center, Berlin, Germany.
  • Del Campo JM; Medical Oncology Department, Hospital Universitario Vall D'Hebron, Barcelona, Spain.
  • Cong XJ; Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT, USA.
  • Ehrnrooth E; Boehringer Ingelheim, Danmark A/S, Denmark.
  • Cohen EE; University of California San Diego Moores Cancer Center, La Jolla, CA, USA.
Lancet Oncol ; 16(5): 583-94, 2015 May.
Article em En | MEDLINE | ID: mdl-25892145
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinazolinas / Carcinoma de Células Escamosas / Protocolos de Quimioterapia Combinada Antineoplásica / Metotrexato / Neoplasias de Cabeça e Pescoço / Recidiva Local de Neoplasia Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Lancet Oncol Assunto da revista: NEOPLASIAS Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinazolinas / Carcinoma de Células Escamosas / Protocolos de Quimioterapia Combinada Antineoplásica / Metotrexato / Neoplasias de Cabeça e Pescoço / Recidiva Local de Neoplasia Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Lancet Oncol Assunto da revista: NEOPLASIAS Ano de publicação: 2015 Tipo de documento: Article