A Conserved Residue Cluster That Governs Kinetics of ATP-dependent Gating of Kir6.2 Potassium Channels.

Zhang, Roger S; Wright, Jordan D; Pless, Stephan A; Nunez, John-Jose; Kim, Robin Y; Li, Jenny B W; Yang, Runying; Ahern, Christopher A; Kurata, Harley T

Zhang, Roger S; Wright, Jordan D; Pless, Stephan A; Nunez, John-Jose; Kim, Robin Y; Li, Jenny B W; Yang, Runying; Ahern, Christopher A; Kurata, Harley T.

Afiliação

Zhang RS; Department of Anesthesiology, Pharmacology, and Therapeutics, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
Wright JD; Department of Anesthesiology, Pharmacology, and Therapeutics, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
Pless SA; Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark.
Nunez JJ; Department of Anesthesiology, Pharmacology, and Therapeutics, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
Kim RY; Department of Anesthesiology, Pharmacology, and Therapeutics, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
Li JBW; Department of Anesthesiology, Pharmacology, and Therapeutics, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
Yang R; Department of Anesthesiology, Pharmacology, and Therapeutics, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
Ahern CA; Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52246.
Kurata HT; Department of Anesthesiology, Pharmacology, and Therapeutics, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. Electronic address: harley.kurata@ubc.ca.

J Biol Chem ; 290(25): 15450-15461, 2015 Jun 19.

Article em En | MEDLINE | ID: mdl-25934393

Assuntos

Canais de Potássio Corretores do Fluxo de Internalização/química; Substituição de Aminoácidos; Animais; Sítios de Ligação; Cinética; Camundongos; Mutação de Sentido Incorreto; Canais de Potássio Corretores do Fluxo de Internalização/genética; Canais de Potássio Corretores do Fluxo de Internalização/metabolismo; Receptores de Sulfonilureias/química; Receptores de Sulfonilureias/genética; Receptores de Sulfonilureias/metabolismo

Palavras-chave

KATP channel; PIP2; diabetes; gating; ion channel; kinetics; ligand-dependent gating; potassium channel

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Canais de Potássio Corretores do Fluxo de Internalização Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Biol Chem Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Canadá

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