Animal Models of Bone Metastasis.
Vet Pathol
; 52(5): 827-41, 2015 Sep.
Article
em En
| MEDLINE
| ID: mdl-26021553
ABSTRACT
Bone is one of the most common sites of cancer metastasis in humans and is a significant source of morbidity and mortality. Bone metastases are considered incurable and result in pain, pathologic fracture, and decreased quality of life. Animal models of skeletal metastases are essential to improve the understanding of the molecular pathways of cancer metastasis and growth in bone and to develop new therapies to inhibit and prevent bone metastases. The ideal animal model should be clinically relevant, reproducible, and representative of human disease. Currently, an ideal model does not exist; however, understanding the strengths and weaknesses of the available models will lead to proper study design and successful cancer research. This review provides an overview of the current in vivo animal models used in the study of skeletal metastases or local tumor invasion into bone and focuses on mammary and prostate cancer, lymphoma, multiple myeloma, head and neck squamous cell carcinoma, and miscellaneous tumors that metastasize to bone.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ósseas
/
Modelos Animais de Doenças
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Vet Pathol
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Estados Unidos